Structure of PDB 3gu7 Chain A Binding Site BS02

Receptor Information

>3gu7 Chain A (length=280) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TVFRQENVDDYYDTGEELGSGVFAVVKKCREKSTGLQYAAKFIKKRRTKS
SRRGVSREDIEREVSILKEIQHPNVITLHEVYENKTDVILILELVAGGEL
FDFLAEKESLTEEEATEFLKQILNGVYYLHSLQIAHFDLKPENIMLLDRN
VPKPRIKIIDFGLAHKIDFGNEFKNIFGTPEFVAPEIVNYEPLGLEADMW
SIGVITYILLSGASPFLGDTKQETLANVSAVNYEFEDEYFSNTSALAKDF
IRRLLVKDPKKRMTIQDSLQHPWIKPPQFE

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

3gu7 Chain A Residue 297 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3gu7 Enzyme activity and crystallographic analyses of a glycine-rich loop mutant of DAPK
Resolution	1.9 Å
Binding residue (original residue number in PDB)	N144 D161
Binding residue (residue number reindexed from 1)	N143 D160
Annotation score	1

Enzymatic activity

Catalytic site (original residue number in PDB)	D139 K141 E143 N144 D161 T180
Catalytic site (residue number reindexed from 1)	D138 K140 E142 N143 D160 T179
Enzyme Commision number	2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

	Molecular Function
GO:0004672	protein kinase activity
GO:0005524	ATP binding

	Biological Process
GO:0006468	protein phosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:3gu7, PDBe:3gu7, PDBj:3gu7
PDBsum	3gu7
PubMed
UniProt	P53355\|DAPK1_HUMAN Death-associated protein kinase 1 (Gene Name=DAPK1)

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