Structure of PDB 3go6 Chain A Binding Site BS02

Receptor Information

>3go6 Chain A (length=287) Species: 1773 (Mycobacterium tuberculosis)

APRVCVVGSVNMDLTFVVDALPRPGETVLAASLTRTPGGKGANQAVAAAR
AGAQVQFSGAFGDDPAAAQLRAHLRANAVGLDRTVTVPGPSGTAIIVVDA
SAENTVLVAPGANAHLTPVPSAVANCDVLLTQLEIPVATALAAARAAQSA
DAVVMVNASPAGQDRSSLQDLAAIADVVIANEHEANDWPSPPTHFVITLG
VRGARYVGADGVFEVPAPTVTPVDTAGAGDVFAGVLAANWPRNPGSPAER
LRALRRACAAGALATLVSGVGDCAPAAAAIDAALRAN

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3go6 Chain A Residue 306

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3go6 Crystal structure and biochemical characterization of M.tuberculosis ribokinase (Rv2436)
• Resolution: 1.98 Å
• Binding residue (original residue number in PDB): D236 A276 V279 C285
• Binding residue (residue number reindexed from 1): D224 A264 V267 C273
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): G239 A240 G241 D242
• Catalytic site (residue number reindexed from 1): G227 A228 G229 D230
• Enzyme Commision number: 2.7.1.15: ribokinase.

Gene Ontology

Molecular Function

• GO:0004747 ribokinase activity
• GO:0005524 ATP binding
• GO:0016301 kinase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006014 D-ribose metabolic process
• GO:0016310 phosphorylation
• GO:0019303 D-ribose catabolic process
• GO:0046835 carbohydrate phosphorylation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:3go6, PDBe:3go6, PDBj:3go6
• PDBsum: 3go6
• UniProt: P71913