Structure of PDB 3g6x Chain A Binding Site BS02

Receptor Information
>3g6x Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLG
VKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLG
FDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLL
VGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPE
SCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELG
ISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEEL
LASLLNRVCQDGRKPHTVRLIIRRYSSEKHYGRESRQCPIPSHVIQVMTP
MVDILMKLFRNMTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
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PDB3g6x DNA Synthesis across an Abasic Lesion by Human DNA Polymerase iota.
Resolution2.08 Å
Binding residue
(original residue number in PDB)		Q59 K60 E97 L99 R103 Q300 S303 E304 E305 S307 K309 R347
Binding residue
(residue number reindexed from 1)		Q35 K36 E73 L75 R79 Q276 S279 E280 E281 S283 K285 R323
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3g6x, PDBe:3g6x, PDBj:3g6x
PDBsum3g6x
PubMed19368886
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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