Structure of PDB 3g2f Chain A Binding Site BS02

Receptor Information
>3g2f Chain A (length=305) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SLDLDNLKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFINEKNI
YRVPLMEHDNIARFIVGDERVTADGRMEYLLVMEYYPNGSLCKYLSLHTS
DWVSSCRLAHSVTRGLAYLHTELPRGDHYKPAISHRDLNSRNVLVKNDGT
CVISDFGLSMRLTGNRLVISEVGTIRYMAPEVLEGAVNLRDCESALKQVD
MYALGLIYWEIFMRCTDLFPGESVPEYQMAFQTEVGNHPTFEDMQVLVSR
EKQRPKFPEAWKENSLAVRSLKETIEDCWDQDAEARLTAQCAEERMAELM
MIWER
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain3g2f Chain A Residue 901 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3g2f Structural consequences of BMPR2 kinase domain mutations causing pulmonary arterial hypertension.
Resolution2.35 Å
Binding residue
(original residue number in PDB)		N338 D351
Binding residue
(residue number reindexed from 1)		N142 D155
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) D333 R337
Catalytic site (residue number reindexed from 1) D137 R141
Enzyme Commision number 2.7.11.30: receptor protein serine/threonine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004675 transmembrane receptor protein serine/threonine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation
GO:0007178 cell surface receptor protein serine/threonine kinase signaling pathway
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3g2f, PDBe:3g2f, PDBj:3g2f
PDBsum3g2f
PubMed31797984
UniProtQ13873|BMPR2_HUMAN Bone morphogenetic protein receptor type-2 (Gene Name=BMPR2)

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