Structure of PDB 3g0a Chain A Binding Site BS02

Receptor Information
>3g0a Chain A (length=257) Species: 187420 (Methanothermobacter thermautotrophicus str. Delta H) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VLKIISWNVNGLRAVHRKGFLKWFMEEKPDILCLQEIKAAPEQLPRKLRH
VEGYRSFFTPAERKGYSGVAMYTKVPPSSLREGFGVERFDTEGRIQIADF
DDFLLYNIYFPNGKMSEERLKYKLEFYDAFLEDVNRERDSGRNVIICGDF
NTAHREIDLARPKENSNVSGFLPVERAWIDKFIENGYVDTFRMFNSDPGQ
YTWWSYRTRARERNVGWRLDYFFVNEEFKGKVKRSWILSDVMGSDHCPIG
LEIELLE
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3g0a Chain A Residue 267 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3g0a Crystal Structure Analysis of DNA Uridine Endonuclease Mth212 Bound to DNA
Resolution2.6 Å
Binding residue
(original residue number in PDB)		N12 E38
Binding residue
(residue number reindexed from 1)		N10 E36
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N10 N12 E38 Y111 D151 N153 D222 D247 H248
Catalytic site (residue number reindexed from 1) N8 N10 E36 Y109 D149 N151 D220 D245 H246
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
4.2.99.18: DNA-(apurinic or apyrimidinic site) lyase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0008081 phosphoric diester hydrolase activity
GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
GO:0016787 hydrolase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity
Biological Process
GO:0006281 DNA repair
GO:0006284 base-excision repair

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:3g0a, PDBe:3g0a, PDBj:3g0a
PDBsum3g0a
PubMed20434457
UniProtO26314|UREND_METTH DNA uridine endonuclease (Gene Name=MTH_212)

[Back to BioLiP]