Structure of PDB 3fpx Chain A Binding Site BS02

Receptor Information

>3fpx Chain A (length=499) Species: 5327 (Trametes hirsuta)

AVGPVADLTITDAAVSPDGFSRQAVVVNGVTPGPLVAGNIGDRFQLNVID
NLTNHTMLKSTSIHWHGFFQHGTNWADGPAFINQCPISPGHSFLYDFQVP
DQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPHASRYDVDNDDTVITLAD
WYHTAAKLGPRFPGGADATLINGKGRAPSDSVAELSVIKVTKGKRYRFRL
VSLSCNPNHTFSIDGHNLTIIEVDSVNSQPLEVDSIQIFAAQRYSFVLDA
NQAVDNYWIRANPNFGNVGFDGGINSAILRYDGAPAVEPTTNQTTSVKPL
NEVDLHPLVSTPVPGSPSSGGVDKAINMAFNFNGSNFFINGASFVPPTVP
VLLQILSGAQTAQDLLPSGSVYVLPSNASIEISFPATAAAPGAPHPFHLH
GHTFAVVRSAGSTVYNYDNPIFRDVVSTGTPAAGDNVTIRFDTNNPGPWF
LHCHIDFHLEGGFAVVMAEDTPDVKAVNPVPQAWSDLCPTYDALDPNDQ

Ligand information

• Ligand ID: CU
• InChI: InChI=1S/Cu/q+2
• InChIKey: JPVYNHNXODAKFH-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Cu+2]
  CACTVS 3.341: [Cu++]
• Formula: Cu
• Name: COPPER (II) ION
• DrugBank: DB14552
• PDB chain: 3fpx Chain A Residue 1500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3fpx Crystallization and preliminary X-ray analysis of a four-copper laccase from Coriolus hirsutus
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): H111 H400 H452
• Binding residue (residue number reindexed from 1): H111 H400 H452
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Enzyme Commision number: 1.10.3.2: laccase.

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:3fpx, PDBe:3fpx, PDBj:3fpx
• PDBsum: 3fpx
• UniProt: B2L9C1