Structure of PDB 3f8i Chain A Binding Site BS02

Receptor Information

>3f8i Chain A (length=206) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HMPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAGIHGRSNDGAYSLV
LAGGYEDDVDNGNYFTYTGSGGRDLSGNKRTAGQSSDQKLTNNNRALALN
CHSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAPAEGNRYDGIYKVV
KYWPERGKSGFLVWRYLLRRDDTEPEPWTREGKDRTRQLGLTMQYPEGYL
EALANK

Ligand information

>3f8i Chain E (length=12) [Search DNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

gtcagcgcatgg

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3f8i UHRF1, a modular multi-domain protein, regulates replication-coupled crosstalk between DNA methylation and histone modifications.
Resolution	2.29 Å
Binding residue (original residue number in PDB)	H450 R457 S458 N494 R496
Binding residue (residue number reindexed from 1)	H34 R41 S42 N78 R80

Enzymatic activity

Enzyme Commision number

2.3.2.27: RING-type E3 ubiquitin transferase.

External links

PDB	RCSB:3f8i, PDBe:3f8i, PDBj:3f8i
PDBsum	3f8i
PubMed	19077538
UniProt	Q8VDF2\|UHRF1_MOUSE E3 ubiquitin-protein ligase UHRF1 (Gene Name=Uhrf1)

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