Structure of PDB 3epi Chain A Binding Site BS02

Receptor Information
>3epi Chain A (length=373) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ASSRVIVHVDLDCFYAQVEMISNPELKDKPLGVQQKYLVVTCNYEARKLG
VKKLMNVRDAKEKCPQLVLVNGEDLTRYREMSYKVTELLEEFSPVVERLG
FDENFVDLTEMVEKRLQQLQSDELSAVTVSGHVYNNQSINLLDVLHIRLL
VGSQIAAEMREAMYNQLGLTGCAGVASNKLLAKLVSGVFKPNQQTVLLPE
SCQHLIHSLNHIKEIPGIGYKTAKCLEALGINSVRDLQTFSPKILEKELG
ISVAQRIQKLSFGEDNSPVILSGPPQSFSEEDSFKKCSSEVEAKNKIEEL
LASLLNRVCQDGRKPHTVRLIIRRYSGRESRQCPIPSHVIQKDVMTPMVD
ILMKLFRNMVNLTLLSVCFCNLK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3epi Lesion bypass of N2-ethylguanine by human DNA polymerase iota.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Q59 K60 Y61 V64 L99 Q300 S301 S303 E304 E305 S307
Binding residue
(residue number reindexed from 1)		Q35 K36 Y37 V40 L75 Q276 S277 S279 E280 E281 S283
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
GO:0003887 DNA-directed DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3epi, PDBe:3epi, PDBj:3epi
PDBsum3epi
PubMed18984581
UniProtQ9UNA4|POLI_HUMAN DNA polymerase iota (Gene Name=POLI)

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