Structure of PDB 3e2e Chain A Binding Site BS02

Receptor Information
>3e2e Chain A (length=832) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMFER
LITTLLPKMIARINDWFEEVKAKRGKRPTAFQFLQEIKPEAVAYITIKTT
LACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKHFKKNVYKKAFM
QVVEADMLSKGLLGGEAWSSWHKEDSIHVGVRCIEMLIESTGMVSLHRQN
AGVVGQDSETIELAPEYAEAIISLMFQPCVVPPKPWTGITGGGYWANGRR
PLALVRTHSKKALMRYEDVYMPEVYKAINIAQNTAWKINKKVLAVANVIT
KWKHCPVEDIPAIEREELPMKPDMNPEALTAWKRAAAAVYRKDKARKSRR
ISLEFMLEQANKFANHKAIWFPYNMDWRGRVYAVSMFNPQGNDMTKGLLT
LAKGKPIGKEGYYWLKIHGANCAGVDKVPFPERIKFIEENHENIMACAKS
PLENTWWAEQDSPFCFLAFCFEYAGVQHHGLSYNCSLPLAFDGSCSGIQH
FSAMLRDEVGGRAVNLLPSETVQDIYGIVAKKVNEILQADAINGTDNEVV
TVTISEKVKLGTKALAGQWLAYGVTRSVTKRSVMTLAYGSKEFGFRQQVL
EDTIQPAIDSGKGLMFTQPNQAAGYMAKLIWESVSVTVVAAVEAMNWLKS
AAKLLAAEVKDKKTGEILRKRCAVHWVTPDGFPVWQEYKKPIQTRLNLMF
LGQFRLQPTINTNKDSEIDAHKQESGIAPNFVHSQDGSHLRKTVVWAHEK
YGIESFALIHDSFGTIPADAANLFKAVRETMVDTYESCDVLADFYDQFAD
QLHESQLDKMPALPAKGNLNLRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3e2e The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation
Resolution3.0 Å
Binding residue
(original residue number in PDB)		R96 G97 K98 Q135 K206 R231 V237 D240 E242 R298 W422 R423 Y427 M431 T636 Y639 S641 F644 G645 Q649 Y739 Q744 R746 F755 R756 Q758 T760 I761 N762 S776
Binding residue
(residue number reindexed from 1)		R74 G75 K76 Q113 K173 R198 V204 D207 E209 R256 W377 R378 Y382 M386 T585 Y588 S590 F593 G594 Q598 Y688 Q693 R695 F704 R705 Q707 T709 I710 N711 S725
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3e2e, PDBe:3e2e, PDBj:3e2e
PDBsum3e2e
PubMed18948533
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

[Back to BioLiP]