Structure of PDB 3dsd Chain A Binding Site BS02

Receptor Information
>3dsd Chain A (length=333) Species: 2261 (Pyrococcus furiosus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKFAHLADIHLGYEQFHKPQREEEFAEAFKNALEIAVQENVDFILIAGDL
FHSSRPSPGTLKKAIALLQIPKEHSIPVFAIEGNSDRTQRGPSVLNLLED
FGLVYVIGMRKEKVENEYLTSERLGNGEYLVKGVYKDLEIHGMKYMSSAW
FEANKEILKRLFRPTDNAILMLHQGVREVSEARGEDYFEIGLGDLPEGYL
YYALGHIHKRYETSYSGSPVVYPGSLERWDFGDYEVRYEWDGIKFKERYG
VNKGFYIVEDFKPRFVEIKVRPFIDVKIKGSEEEIRKAIKRLIPLIPKNA
YVRLNIGWRKPFDLTEIKELLNVEYLKIDTWRI
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3dsd Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3dsd Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		D8 H10 D49 H208
Binding residue
(residue number reindexed from 1)		D8 H10 D49 H208
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0016787 hydrolase activity
Biological Process
GO:0000729 DNA double-strand break processing
GO:0006302 double-strand break repair

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Molecular Function
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Biological Process
External links
PDB RCSB:3dsd, PDBe:3dsd, PDBj:3dsd
PDBsum3dsd
PubMed18854158
UniProtQ8U1N9|MRE11_PYRFU DNA double-strand break repair protein Mre11 (Gene Name=mre11)

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