Structure of PDB 3dqw Chain A Binding Site BS02

Receptor Information

>3dqw Chain A (length=279) Species: 9031 (Gallus gallus)

LAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSP
EAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVIEYMSKGSLLDFLKGEM
GKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVAD
FGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTE
LTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKDPE
ERPTFEYLQAFLEDYFTSTEPQYQPGENL

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 3dqw Chain A Residue 1

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3dqw Activation of tyrosine kinases by mutation of the gatekeeper threonine.
• Resolution: 2.017 Å
• Binding residue (original residue number in PDB): N391 D404
• Binding residue (residue number reindexed from 1): N137 D150
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D386 R388 A390 N391 D404 F424
• Catalytic site (residue number reindexed from 1): D132 R134 A136 N137 D150 F170
• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:3dqw, PDBe:3dqw, PDBj:3dqw
• PDBsum: 3dqw
• PubMed: 18794843
• UniProt: P00523|SRC_CHICK Proto-oncogene tyrosine-protein kinase Src (Gene Name=SRC)