Structure of PDB 3cxl Chain A Binding Site BS02

Receptor Information
>3cxl Chain A (length=402) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GVWKSYLYQLQQEAPHPRRITCTCEVENRPKYYGREFHGMISREAADQLL
IVAEGSYLIRESQRQPGTYTLALRFGSQTRNFRLYYDGKHFVGEKRFESI
HDLVTDGLITLYIETKAAEYIAKMTINPIYEHVGYTTLMPVLKETEKIHN
FKVHTFRGPHWCEYCANFMWGLIAQGVKCADCGLNVHKQCSKMVPNDCKP
DLKHVKKVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSG
FSDLIEDVKMAFDRDGEKADISVNMYEDINIITGALKLYFRDLPIPLITY
DAYPKFIESAKIMDPDEQLETLHEALKLLPPAHCETLRYLMAHLKRVTLH
EKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRYQRLVVELLIKNEDI
LF
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3cxl Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3cxl Crystal structure of human chimerin 1 (CHN1).
Resolution2.6 Å
Binding residue
(original residue number in PDB)		C219 C222 H244 C247
Binding residue
(residue number reindexed from 1)		C162 C165 H187 C190
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005096 GTPase activator activity
GO:0005515 protein binding
GO:0046872 metal ion binding
GO:0046875 ephrin receptor binding
Biological Process
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0008045 motor neuron axon guidance
GO:0043547 positive regulation of GTPase activity
GO:0048013 ephrin receptor signaling pathway
GO:0050770 regulation of axonogenesis
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3cxl, PDBe:3cxl, PDBj:3cxl
PDBsum3cxl
PubMed
UniProtP15882|CHIN_HUMAN N-chimaerin (Gene Name=CHN1)

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