Structure of PDB 3cm5 Chain A Binding Site BS02

Receptor Information
>3cm5 Chain A (length=294) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HCPFDTLLILDFETTSDAANQDYPCEVIQFAIVAYDVPNDKIREDISFNK
YVKPVLNRTLTKNCVDFTGIPQRSIDTADTFDVVYEQFQQWLITLGLEEG
KFAFVCDSRQDLWRIAQYQMKLSNIQMPAFFRQYINLYKIFTNEMDRMGP
KELSATTNIGKMNEYYDLPTIGRAHDAMDDCLNIATILQRMINMGAKVTV
NELLTCCASWRRQPLVYNKEWRSSFMDAGKIFERVLPLVVTTIRAGDFRL
EMYGVCRYCRKGMDVCGTSHQQTPHDLYKNEEDPIHFAKIAGYY
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain3cm5 Chain A Residue 300 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3cm5 Crystal structure of CRN-4: implications for domain function in apoptotic DNA degradation
Resolution2.81 Å
Binding residue
(original residue number in PDB)		D15 E17 D184
Binding residue
(residue number reindexed from 1)		D11 E13 D180
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) D15 E17 D115 H179 D184
Catalytic site (residue number reindexed from 1) D11 E13 D111 H175 D180
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0000175 3'-5'-RNA exonuclease activity
GO:0003676 nucleic acid binding
GO:0003697 single-stranded DNA binding
GO:0004520 DNA endonuclease activity
GO:0004527 exonuclease activity
GO:0004536 DNA nuclease activity
GO:0004540 RNA nuclease activity
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0006308 DNA catabolic process
GO:0006309 apoptotic DNA fragmentation
GO:0006401 RNA catabolic process
GO:0006915 apoptotic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:3cm5, PDBe:3cm5, PDBj:3cm5
PDBsum3cm5
PubMed18981218
UniProtQ10905|CRN4_CAEEL 3'-5' exonuclease crn-4 (Gene Name=crn-4)

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