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Receptor Information

>3c5t Chain A (length=104) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

ATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEP
GSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECE
ESKR

Ligand ID

10M

InChI

InChI=1S/C22H42O10S/c1-2-3-4-5-6-7-8-9-10-33-22-19(29)17(27)20(14(12-24)31-22)32-21-18(28)16(26)15(25)13(11-23)30-21/h13-29H,2-12H2,1H3/t13-,14-,15-,16+,17-,18-,19-,20-,21-,22+/m1/s1

InChIKey

YZNNXXWNKQOETJ-HYLFJBCQSA-N

SMILES

Software	SMILES
OpenEye OEToolkits 1.5.0	CCCCCCCCCCSC1C(C(C(C(O1)CO)OC2C(C(C(C(O2)CO)O)O)O)O)O
ACDLabs 10.04	S(CCCCCCCCCC)C2OC(C(OC1OC(CO)C(O)C(O)C1O)C(O)C2O)CO
OpenEye OEToolkits 1.5.0	CCCCCCCCCCS[C@H]1[C@@H]([C@H]([C@@H]([C@H](O1)CO)O[C@@H]2[C@@H]([C@H]([C@@H]([C@H](O2)CO)O)O)O)O)O
CACTVS 3.341	CCCCCCCCCCS[CH]1O[CH](CO)[CH](O[CH]2O[CH](CO)[CH](O)[CH](O)[CH]2O)[CH](O)[CH]1O
CACTVS 3.341	CCCCCCCCCCS[C@@H]1O[C@H](CO)[C@@H](O[C@H]2O[C@H](CO)[C@@H](O)[C@H](O)[C@H]2O)[C@H](O)[C@H]1O

Formula

C22 H42 O10 S

Name

decyl 4-O-alpha-D-glucopyranosyl-1-thio-beta-D-glucopyranoside;
(2R,3R,4S,5S,6R)-2-((2R,3S,4R,5R,6S)-6-Decylsulfanyl-4,5-dihydroxy-2-hydroxymethyl-tetrahydro-pyran-3-yloxy)-6-hydroxymethyl-tetrahydro-pyran-3,4,5-triol, n-Decyl-beta-D-thiomaltoside

PDB chain

3c5t Chain A Residue 1 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	3c5t Crystal Structure of the Ligand-bound Glucagon-like Peptide-1 Receptor Extracellular Domain
Resolution	2.1 Å
Binding residue (original residue number in PDB)	F80 N82 H99 Y101
Binding residue (residue number reindexed from 1)	F53 N55 H72 Y74
Annotation score	1

Enzyme Commision number

	Molecular Function
GO:0004930	G protein-coupled receptor activity
GO:0004967	glucagon receptor activity
GO:0008528	G protein-coupled peptide receptor activity

	Biological Process
GO:0007186	G protein-coupled receptor signaling pathway

	Cellular Component
GO:0016020	membrane

PDB	RCSB:3c5t, PDBe:3c5t, PDBj:3c5t
PDBsum	3c5t
PubMed	18287102
UniProt	P43220\|GLP1R_HUMAN Glucagon-like peptide 1 receptor (Gene Name=GLP1R)

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Structure of PDB 3c5t Chain A Binding Site BS02