Structure of PDB 3c2v Chain A Binding Site BS02

Receptor Information
>3c2v Chain A (length=270) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PVYEHLLPVNGAWRQDVTNWLSEDVPSFDFGGYVVGSDLKEANLYCKQDG
MLCGVPFAQEVFNQCELQVEWLFKEGSFLEPSKNDSGKIVVAKITGPAKN
ILLAERTALNILSRSSGIATASHKIISLARSTGYKGTIAGTRKTTPGLRR
LEKYSMLVGGCDTHRYDLSSMVMLKDNHIWATGSITNAVKNARAVCGFAV
KIEVECLSEDEATEAIEAGADVIMLDNHFLLECSGGLNLDNLYLCDDIDI
YSTSSIHQGTPVIDFSLKLA
Ligand information
Ligand IDPHT
InChIInChI=1S/C8H6O4/c9-7(10)5-3-1-2-4-6(5)8(11)12/h1-4H,(H,9,10)(H,11,12)
InChIKeyXNGIFLGASWRNHJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341OC(=O)c1ccccc1C(O)=O
ACDLabs 10.04O=C(O)c1ccccc1C(=O)O
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C(=O)O)C(=O)O
FormulaC8 H6 O4
NamePHTHALIC ACID
ChEMBLCHEMBL1045
DrugBankDB02746
ZINCZINC000000090750
PDB chain3c2v Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3c2v Comprehensive X-ray Structural Studies of the Quinolinate Phosphoribosyl Transferase (BNA6) from Saccharomyces cerevisiae.
Resolution2.29 Å
Binding residue
(original residue number in PDB)		T142 R143 H165 R166 M174 K176
Binding residue
(residue number reindexed from 1)		T141 R142 H164 R165 M173 K175
Annotation score2
Binding affinityMOAD: Kd=0.78mM
Enzymatic activity
Catalytic site (original residue number in PDB) R107 K144 K176 E206 D227
Catalytic site (residue number reindexed from 1) R106 K143 K175 E205 D226
Enzyme Commision number 2.4.2.19: nicotinate-nucleotide diphosphorylase (carboxylating).
Gene Ontology
Molecular Function
GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0016757 glycosyltransferase activity
GO:0016763 pentosyltransferase activity
Biological Process
GO:0009435 NAD biosynthetic process
GO:0019363 pyridine nucleotide biosynthetic process
GO:0034213 quinolinate catabolic process
GO:0034354 'de novo' NAD biosynthetic process from tryptophan
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3c2v, PDBe:3c2v, PDBj:3c2v
PDBsum3c2v
PubMed18321072
UniProtP43619|NADC_YEAST Nicotinate-nucleotide pyrophosphorylase [carboxylating] (Gene Name=BNA6)

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