Structure of PDB 3brd Chain A Binding Site BS02

Receptor Information
>3brd Chain A (length=427) Species: 6239 (Caenorhabditis elegans) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYL
IGQGWKLKKDRVAQLYKTLQQATELVAYIGIGSDTSERQQLDFPNIYDYC
AAKTLYISDSDKRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKTD
CKYLCIASGTKVALFNRLRSQTVSTRYLHVEGNAFHASSTKWGAFTIHLF
DDQETDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDAS
CSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAINEHRHQINDGA
AWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHGEASRVELHGR
DFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRTTG
DVEVPISLVRDDGVVYSSGLTFSYKSL
Ligand information
Receptor-Ligand Complex Structure
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PDB3brd RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
Resolution2.21 Å
Binding residue
(original residue number in PDB)
K227 Y229 S367 R399 Q401
Binding residue
(residue number reindexed from 1)
K33 Y35 S142 R169 Q171
Binding affinityPDBbind-CN: Kd=0.032uM
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0006357 regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634 nucleus

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:3brd, PDBe:3brd, PDBj:3brd
PDBsum3brd
PubMed18381292
UniProtV6CLJ5|LAG1_CAEEL Suppressor of hairless protein homolog (Gene Name=lag-1)

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