Structure of PDB 3brd Chain A Binding Site BS02
Receptor Information
>3brd Chain A (length=427) Species:
6239
(Caenorhabditis elegans) [
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VQSLTSDRMIDFLSNKEKYECVISIFHAKVAQKSYGNEKRFFCPPPCIYL
IGQGWKLKKDRVAQLYKTLQQATELVAYIGIGSDTSERQQLDFPNIYDYC
AAKTLYISDSDKRKYFDLNAQFFYGCGMEIGGFVSQRIKVISKPSKKKTD
CKYLCIASGTKVALFNRLRSQTVSTRYLHVEGNAFHASSTKWGAFTIHLF
DDQETDNFAVRDGFVYYGSVVKLVDSVTGIALPRLRIRKVDKQQVILDAS
CSEEPVSQLHKCAFQMIDNELVYLCLSHDKIIQHQATAINEHRHQINDGA
AWTIISTDKAEYRFFEAMGQVANPISPCPVVGSLEVDGHGEASRVELHGR
DFKPNLKVWFGATPVETTFRSEESLHCSIPPVSQVRNEQTHWMFTNRTTG
DVEVPISLVRDDGVVYSSGLTFSYKSL
Ligand information
>3brd Chain C (length=15) [
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aatctttcccacagt
Receptor-Ligand Complex Structure
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PDB
3brd
RAM-induced Allostery Facilitates Assembly of a Notch Pathway Active Transcription Complex.
Resolution
2.21 Å
Binding residue
(original residue number in PDB)
K227 Y229 S367 R399 Q401
Binding residue
(residue number reindexed from 1)
K33 Y35 S142 R169 Q171
Binding affinity
PDBbind-CN
: Kd=0.032uM
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0000978
RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001228
DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0003677
DNA binding
GO:0003700
DNA-binding transcription factor activity
Biological Process
GO:0006355
regulation of DNA-templated transcription
GO:0006357
regulation of transcription by RNA polymerase II
Cellular Component
GO:0005634
nucleus
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Molecular Function
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Biological Process
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Cellular Component
External links
PDB
RCSB:3brd
,
PDBe:3brd
,
PDBj:3brd
PDBsum
3brd
PubMed
18381292
UniProt
V6CLJ5
|LAG1_CAEEL Suppressor of hairless protein homolog (Gene Name=lag-1)
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