Structure of PDB 3avy Chain A Binding Site BS02

Receptor Information
>3avy Chain A (length=1203) Species: 39803,83334 [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AEITASLVKELRERTGAGMMDCKKALTEANGDIELAIENMRKSGAIKAAK
KAGNVAADGVIKTKIDGNYGIILEVNCQTDFVAKDAGFQAFADKVLDAAV
AGKITDVEVLKAQFEEERVALVAKIGENINIRRVAALEGDVLGSYQHGAR
IGVLVAAKGADEELVKHIAMHVAASKPEFIKPEDVSAEVVEKEYQVQLDI
AMQSGKPKEIAEKMVEGRMKKFTGEVSLTGQPFVMEPSKTVGQLLKEHNA
EVTGFIRFEVGEGIEKVETDFAAEVAAMSKQSHMSFERTKPHVNVGTIGH
VDHGKTTLTAAITTVLAKTYGGNTSHVEYDTPTRHYAHVDCPGHADYVKN
MITGAAQMDGAILVVAATDGPMPQTREHILLGRQVGVPYIIVFLNKCDMV
DDEELLELVEMEVRELLSQYDFPGDDTPIVRGSALKALEGDAEWEAKILE
LAGFLDSYIPEPERAIDKPFLLPIEDVFSISGRGTVVTGRVERGIIKVGE
EVEIVGIKETQKSTCTGVEMFRKLLDEGRAGENVGVLLRGIKREEIERGQ
VLAKPGTIKPHTKFESEVYILSKDEGGRHTPFFKGYRPQFYFRTTDVTGT
IELPEGVEMVMPGDNIKMVVTLIHPIAMDDGLRFAIREGGRTVGAGVVAK
VLSGASSRNSLSAQLRRAANTRIEVEGNLALSIANDLLLAYGQSPFNSEA
ECISFSPRFDGTPDDFRINYLKAEIMSKYDDFSLGIDTEAVAWEKFLAAE
AECALTNARLYRPDYSEDFNFSLGESCIHMARRKIAKLIGDVPSVEGMLR
HCRFSGGATTTNNRSYGHPSFKFALPQACTPRALKYVLALRASTHFDIRI
SDISPFNKAVTVPKNSKTDRCIAIEPGWNMFFQLGIGGILRDRLRCWGID
LNDQTINQRRAHEGSVTNNLATVDLSAASDSISLALCELLLPPGWFEVLM
DLRSPKGRLPDGSVVTYEKISSMGNGYTFELESLIFASLARSVCEILDLD
SSEVTVYGDDIILPSCAVPALREVFKYVGFTTNTKKTFSEGPFRESCGKH
YYSGVDVTPFYIRHRIVSPADLILVLNNLYRWATIDGVWDPRAHSVYLKY
RKLLPKQLQRNTIPDGYGDGALVGSVLINPFAKNRGWIRYVPVITDHTRD
RERAELGSYLYDLFSRCLSESNAIDQLICRSNPTKISRSTGKFDIQYIAC
SSR
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3avy Molecular basis for RNA polymerization by Q beta replicase
Resolution2.616 Å
Binding residue
(original residue number in PDB)		T620 D621 R662 G851 A852 T854 T855 N857 R858 H862 I916 I918 M924 R935 N946 G1018 Y1051 G1160 Y1161 N1243 P1244 T1245 K1246 Q1257
Binding residue
(residue number reindexed from 1)		T595 D596 R637 G807 A808 T810 T811 N813 R814 H818 I872 I874 M880 R891 N902 G974 Y1007 G1116 Y1117 N1182 P1183 T1184 K1185 Q1196
Enzymatic activity
Catalytic site (original residue number in PDB) D306 K309 T310 H369
Catalytic site (residue number reindexed from 1) D302 K305 T306 H344
Enzyme Commision number ?
2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0003723 RNA binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0034062 5'-3' RNA polymerase activity
GO:0046872 metal ion binding
GO:0097216 guanosine tetraphosphate binding
Biological Process
GO:0001172 RNA-templated transcription
GO:0006412 translation
GO:0006414 translational elongation
GO:0019079 viral genome replication
GO:0039694 viral RNA genome replication
GO:0046677 response to antibiotic
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:3avy, PDBe:3avy, PDBj:3avy
PDBsum3avy
PubMed22245970
UniProtP0A6N3;
P0A6P3;
P14647|RDRP_BPQBE RNA-directed RNA polymerase subunit beta

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