Structure of PDB 3anu Chain A Binding Site BS02

Receptor Information

>3anu Chain A (length=367) Species: 9031 (Gallus gallus)

MWLGALLDTLPTPALTIDRTTARRNAERMRERCRALGVRLRPHVKTHKTL
EGGLLATGGTRRGIAVSTLAEARFFADGGFDDILLAYPVPTARLEECAGL
ARRLDAFHVLLDRPEALASLRQRPLGHGKRWLVWLKLDCGRAGVRPTDPA
ALELAQAIANDAPEEVTLVGVYAHCGNTYCSGADTIQAIARTTTNAVLSF
VAALRQAGVPCPQASIGSTPSCSHPIPEMSQLTELHPGNYIFYDLQQTQL
GSCQPQDVAIRVLTRVIGHYAHRGQLLVDCGWAALSLHGAGGPQGCAAID
GHPELRLVGLTQEHGLLEHQMDFGRFPVGSVLALIPYHACATAAMHPVYY
VHEEGKVVALWHPVRGW

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 3anu Chain A Residue 451

Receptor-Ligand Complex Structure

Structure summary

• PDB: 3anu Crystal structure of a zinc-dependent D-serine dehydratase from chicken kidney
• Resolution: 1.9 Å
• Binding residue (original residue number in PDB): H347 C349
• Binding residue (residue number reindexed from 1): H338 C340
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 4.3.1.18: D-serine ammonia-lyase.

Gene Ontology

Molecular Function

• GO:0008270 zinc ion binding
• GO:0008721 D-serine ammonia-lyase activity
• GO:0016829 lyase activity
• GO:0030170 pyridoxal phosphate binding
• GO:0046872 metal ion binding

Biological Process

• GO:0036088 D-serine catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0030425 dendrite
• GO:0042995 cell projection

External links

• PDB: RCSB:3anu, PDBe:3anu, PDBj:3anu
• PDBsum: 3anu
• PubMed: 21676877
• UniProt: A0A8V1ABE9|DSD1_CHICK D-serine dehydratase (Gene Name=DSD)