Structure of PDB 3af5 Chain A Binding Site BS02

Receptor Information
>3af5 Chain A (length=638) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TQVDQILRDIRAVVNQMVPKEAKITEIEFEGPELVIYVKNPEGELIKDLA
KVLKKRISVRPDPEVLLPPEEAEKLIFEIVPKEAEITNIAFDPSVGEVLI
EAKKPGLVIGKNGETLRLITQKVKWAPKVVRTPPLQSQTIYSIRQILQTE
SKDRRKFLRQVGRNIYRKPEYKSRWIRITGLGGFREVGRSALLVQTDESF
VLVDFGVNVAMLNDPYKAFPHFDAPEFQYVLREGLLDAIIITHAHLDHCG
MLPYLFRYNLFDGPIYTTPPTRDLMVLLQKDFIEIQQSNGQDPLYRPRDI
KEVIKHTITLDYGEVRDISPDIRLTLHNAGHILGSAIVHLHIGNGLHNIA
ITGDFKFIPTRLLEPANAKFPRLETLVMESTYGGANDIQMPREEAEKRLI
EVIHNTIKRGGKVLIPAMAVGRAQEVMMVLEEYARIGGIEVPIYLDGMIW
EATAIHTAYPEYLSRRLREQIFKEGYNPFLSEIFHPVANSRERQDIIDSN
EPAIIIASSGMLVGGPSVEYFKQLAPDPKNSIIFVSYQAEGTLGRQVQSG
IREIPMVGEEGRTEVIKVNMEVHTIDGFSGHADRRELMNYVAKVRPRPER
IITVHGEPQKCLDLATSIHRKFGISTRAPNNLDTIRLR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain3af5 Chain A Residue 663 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB3af5 Crystal structure of an archaeal cleavage and polyadenylation specificity factor subunit from Pyrococcus horikoshii
Resolution2.6 Å
Binding residue
(original residue number in PDB)		E387 E612
Binding residue
(residue number reindexed from 1)		E374 E599
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004521 RNA endonuclease activity
GO:0004527 exonuclease activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006353 DNA-templated transcription termination

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Molecular Function
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Biological Process
External links
PDB RCSB:3af5, PDBe:3af5, PDBj:3af5
PDBsum3af5
PubMed20544974
UniProtO50112|FTTA_PYRHO Transcription termination factor FttA (Gene Name=fttA)

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