Structure of PDB 3a7q Chain A Binding Site BS02

Receptor Information
>3a7q Chain A (length=685) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NNPVLLLDTFDFGPREDNWFFYPGGNIGLYCPYSDSAMVFVSNEVGEHSI
TTRDLSVNENTIIQFEINVGCSTDSSSADPVRLEFSRDFGATWHLLLPLC
HHPSSTYYAGTTQGWRREVVHFGKLHLAGSVRFRWYQGFYPAGSQPVTWA
IDNVYIGPQCEEMCYGHGSCINGTKCICDPGYSGPTCKISTKNPDFLKDD
FEGDRFLLMSGGKPSRKCGILSSGNNLFFNEDGLRMLVTRDLDLSHARFV
QFFMRLGCGKGVPDPRSQPVLLQYSLNGGLSWSLLQEFLFSNSSNVGRYI
ALEMPLKARSGSTRLRWWQPSENGHFYSPWVIDQILIGGNISGNTVLEDD
FSTLDSRKWLLHPGGTKMPVCGSTGDALVFIEKASTRYVVTTDIAVNEDS
FLQIDFAASCSVTDSCYAIELEYSVDLGLSWHPLVRDCLPTNVECSRYHL
QRILVSDTFNKWTRITLPLPSYTRSQATRFRWHQPAPFDKQQTWAIDNVY
IGDGCLDMCSGHGRCVQGSCVCDEQWGGLYCDEPETSLPTQLKDNFNRAP
SNQNWLTVSGGKLSTVCGAVASGLALHFSGGCSRLLVTVDLNLTNAEFIQ
FYFMYGCLITPSNRNQGVLLEYSVNGGITWNLLMEIFYDQYSKPGFVNIL
LPPDAKEIATRFRWWQPRHDGLDQNDWAIDNVLIS
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain3a7q Chain A Residue 4002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB3a7q Structural Basis for Specific Recognition of Reelin by Its Receptors
Resolution2.6 Å
Binding residue
(original residue number in PDB)		D2173 E2175 N2202 D2310
Binding residue
(residue number reindexed from 1)		D200 E202 N225 D333
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.21.-
Gene Ontology
Molecular Function
GO:0070325 lipoprotein particle receptor binding
Biological Process
GO:0001764 neuron migration
GO:0007417 central nervous system development

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Molecular Function
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Biological Process
External links
PDB RCSB:3a7q, PDBe:3a7q, PDBj:3a7q
PDBsum3a7q
PubMed20223215
UniProtQ60841|RELN_MOUSE Reelin (Gene Name=Reln)

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