Structure of PDB 3a6p Chain A Binding Site BS02

Receptor Information
>3a6p Chain A (length=1072) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AMDQVNALCEQLVKAVTVMMDPNSTQRYRLEALKFCEEFKEKCPICVPCG
LRLAEKTQVAIVRHFGLQILEHVVKFRWNGMSRLEKVYLKNSVMELIANG
TLNILEEENHIKDALSRIVVEMIKREWPQHWPDMLIELDTLSKQGETQTE
LVMFILLRLAEDVVTFQTLPPQRRRDIQQTLTQNMERIFSFLLNTLQENV
NKYQQVKTDTSQESKAQANCRVGVAALNTLAGYIDWVSMSHITAENCKLL
EILCLLLNEQELQLGAAECLLIAVSRKGKLEDRKPLMVLFGDVAMHYILS
AAQTADGGGLVEKHYVFLKRLCQVLCALGNQLCALLGADSDVETPSNFGK
YLESFLAFTTHPSQFLRSSTQMTWGALFRHEILSRDPLLLAIIPKYLRAS
MTNLVKMGFPSKTDSPSCEYSRFDFDSDEDFNAFFNSSRAQQGEVMRLAC
RLDPKTSFQMAGEWLKYQLSTFSLCSVFSPSFVQWEAMTLFLESVITQMF
RTLNREEIPVNDGIELLQMVLNFDTKDPLILSCVLTNVSALFPFVTYRPE
FLPQVFSKLFSSVTFETVEESKAPRTRAVRNVRRHACSSIIKMCRDYPQL
VLPNFDMLYNHVKQLLSNELLLTQMEKCALMEALVLISNQFKNYERQKVF
LEELMAPVASIWLSQDMHRVLSDVDAFIAYVGTDQKDPGLEDPCGLNRAR
MSFCVYSILGVVKRTCWPTDLEEAKAGGFVVGYTSSGNPIFRNPCTEQIL
KLLDNLLALIRTHNTLYAPEMLAKMAEPFTKALDMLDAEKSAILGLPQPL
LELNDSPVFKTVLERMQRFFSTLYENCFHILGKAGPSMQQDFYTVEDLAT
QLLSSAFVNLNNIPDYRLRPMLRVFVKPLVLFCPPEHYEALVSPILGPLF
TYLHMRLSQKWQVINQRESQEMLEEQLVRMLTREVMDLITVCCVSELTDL
GKCLMKHEDVCTALLITAFNSLAWKDTLSCQRTTSQLCWPLLKQVLSGTL
LADAVTWLFTSVLKGLQMHGQHDGCMASLVHLAFQIYEALRPRYLEIRAV
MEQIPEIQKDSLDQFDCKLLNP
Ligand information
>3a6p Chain D (length=22) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
gguaaacauccgacuggaagcu
......................
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB3a6p A high-resolution structure of the pre-microRNA nuclear export machinery
Resolution2.92 Å
Binding residue
(original residue number in PDB)		R380 S606 I609 R734 R893 D1087 A1091
Binding residue
(residue number reindexed from 1)		R379 S588 I591 R714 R873 D1023 A1027
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0003723 RNA binding
GO:0003729 mRNA binding
GO:0005049 nuclear export signal receptor activity
GO:0005515 protein binding
GO:0031267 small GTPase binding
GO:0070883 pre-miRNA binding
GO:1905172 RISC complex binding
Biological Process
GO:0006405 RNA export from nucleus
GO:0006611 protein export from nucleus
GO:0006886 intracellular protein transport
GO:0010586 miRNA metabolic process
GO:0015031 protein transport
GO:0031047 regulatory ncRNA-mediated gene silencing
GO:0035281 pre-miRNA export from nucleus
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016442 RISC complex
GO:0042565 RNA nuclear export complex

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:3a6p, PDBe:3a6p, PDBj:3a6p
PDBsum3a6p
PubMed19965479
UniProtQ9HAV4|XPO5_HUMAN Exportin-5 (Gene Name=XPO5)

[Back to BioLiP]