Structure of PDB 2zxp Chain A Binding Site BS02

Receptor Information
>2zxp Chain A (length=648) Species: 300852 (Thermus thermophilus HB8) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MRDRVRWRVLSLPPLAQWREVMAALEVGPEAALAYWHRGFRRKEDLDPPL
ALLPLKGLREAAALLEEALRQGKRIRVHGDYDADGLTGTAILVRGLAALG
ADVHPFIPMERVPEHLEASDLFLTVDCGITNHAELRELLENGVEVIVTDH
HTPGKTPPPGLVVHPALTPDLKEKPTGAGVAFLLLWALHERLGLPPPLEY
ADLAAVGTIADVAPLWGWNRALVKEGLARIPASSWVGLRLLAEAVGYTGK
AVEVAFRIAPRINAASRLGEAEKALRLLLTDDAAEAQALVGELHRLNARR
QTLEEAMLRKLLPQADPEAKAIVLLDPEGHPGVMGIVASRILEATLRPVF
LVAQGKGTVRSLAPISAVEALRSAEDLLLRYGGHKEAAGFAMDEALFPAF
KARVEAYAARFPDPVREVALLDLLPEPGLLPQVFRELALLEPYGEGNPEP
LFLLFGAPEEARRLGEGRHLAFRLKGVRVLAWKQGDLALPPEVEVAGLLS
ENAWNGHLAYEVQAVDLRKPEALEGGIAPFAYPLPLLEALARARLGEGVY
VPEDNPEGLDYAWKAGFRLLPPEEAGLWLGLPPRPVLGRRVEVALGREAR
ARLSAPPVLHTPEARLKALVHRRLLFAYERRHPGLFSEALLAYWEVNR
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain2zxp Chain A Residue 668 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2zxp Structure of RecJ exonuclease defines its specificity for single-stranded DNA
Resolution2.3 Å
Binding residue
(original residue number in PDB)		D80 D82 D136 H161
Binding residue
(residue number reindexed from 1)		D80 D82 D126 H151
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0004527 exonuclease activity
GO:0046872 metal ion binding

View graph for
Molecular Function
External links
PDB RCSB:2zxp, PDBe:2zxp, PDBj:2zxp
PDBsum2zxp
PubMed20129927
UniProtQ5SJ47|RECJ_THET8 Single-stranded-DNA-specific exonuclease RecJ (Gene Name=recJ)

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