Structure of PDB 2zr8 Chain A Binding Site BS02

Receptor Information
>2zr8 Chain A (length=319) Species: 4896 (Schizosaccharomyces pombe) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LVLPTYDDVASASERIKKFANKTPVLTSSTVNKEFVAEVFFKCENFQKMG
AFKFRGALNALSQLNEAQRKAGVLTFSSGNHAQAIALSAKILGIPAKIIM
PLDAPEAKVAATKGYGGQVIMYDRYKDDREKMAKEISEREGLTIIPPYDH
PHVLAGQGTAAKELFEEVGPLDALFVCLGGGGLLSGSALAARHFAPNCEV
YGVEPEAGNDGQQSFRKGSIVHIDTPKTIADGAQTQHLGNYTFSIIKEKV
DDILTVSDEELIDCLKFYAARMKIVVEPTGCLSFAAARAMKEKLKNKRIG
IIISGGNVDIERYAHFLSQ
Ligand information
Ligand IDSER
InChIInChI=1S/C3H7NO3/c4-2(1-5)3(6)7/h2,5H,1,4H2,(H,6,7)/t2-/m0/s1
InChIKeyMTCFGRXMJLQNBG-REOHCLBHSA-N
SMILES
SoftwareSMILES
CACTVS 3.341N[CH](CO)C(O)=O
OpenEye OEToolkits 1.5.0C(C(C(=O)O)N)O
CACTVS 3.341N[C@@H](CO)C(O)=O
ACDLabs 10.04O=C(O)C(N)CO
OpenEye OEToolkits 1.5.0C([C@@H](C(=O)O)N)O
FormulaC3 H7 N O3
NameSERINE
ChEMBLCHEMBL11298
DrugBankDB00133
ZINCZINC000000895034
PDB chain2zr8 Chain A Residue 370 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2zr8 Crystal structure of a homolog of mammalian serine racemase from Schizosaccharomyces pombe
Resolution2.2 Å
Binding residue
(original residue number in PDB)		S82 R133 D235 G236 A237 Q238 T239
Binding residue
(residue number reindexed from 1)		S78 R129 D231 G232 A233 Q234 T235
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) K57 S82 E208 G212 D214 G236 I307 S308
Catalytic site (residue number reindexed from 1) K53 S78 E204 G208 D210 G232 I303 S304
Enzyme Commision number 4.3.1.17: L-serine ammonia-lyase.
4.3.1.18: D-serine ammonia-lyase.
5.1.1.18: serine racemase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0003941 L-serine ammonia-lyase activity
GO:0005524 ATP binding
GO:0008721 D-serine ammonia-lyase activity
GO:0016829 lyase activity
GO:0016853 isomerase activity
GO:0018114 threonine racemase activity
GO:0030170 pyridoxal phosphate binding
GO:0030378 serine racemase activity
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
Biological Process
GO:0006563 L-serine metabolic process
GO:0070178 D-serine metabolic process
Cellular Component
GO:0005575 cellular_component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2zr8, PDBe:2zr8, PDBj:2zr8
PDBsum2zr8
PubMed19640845
UniProtO59791|SRR_SCHPO Serine racemase (Gene Name=sry1)

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