Structure of PDB 2zkd Chain A Binding Site BS02
Receptor Information
>2zkd Chain A (length=210) Species:
10090
(Mus musculus) [
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SGMACVGRTTECTIVPANHFGPIPGVPVGTMWRFRVQVSESGVHRPHVAG
IHGRSNDGAYSLVLAGGYEDDVDNGNYFTYTGSGGRDLSGNKRTAGQSSD
QKLTNNNRALALNCHSPINEKGAEAEDWRQGKPVRVVRNMKGGKHSKYAP
AEGNRYDGIYKVVKYWPERGKSGFLVWRYLLRRDDTEPEPWTREGKDRTR
QLGLTMQYPE
Ligand information
>2zkd Chain D (length=12) [
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gcaatccggtag
Receptor-Ligand Complex Structure
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PDB
2zkd
Recognition of hemi-methylated DNA by the SRA protein UHRF1 by a base-flipping mechanism
Resolution
1.6 Å
Binding residue
(original residue number in PDB)
S404 M406 A407 F437 R438 H450 V451 A452 G453 A468 G470 Y471 D474 Y483 T484 S486 G487 R496 K544
Binding residue
(residue number reindexed from 1)
S1 M3 A4 F34 R35 H47 V48 A49 G50 A65 G67 Y68 D71 Y80 T81 S83 G84 R93 K141
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:2zkd
,
PDBe:2zkd
,
PDBj:2zkd
PDBsum
2zkd
PubMed
18772891
UniProt
Q8VDF2
|UHRF1_MOUSE E3 ubiquitin-protein ligase UHRF1 (Gene Name=Uhrf1)
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