Structure of PDB 2z70 Chain A Binding Site BS02

Receptor Information

>2z70 Chain A (length=245) Species: 562 (Escherichia coli)

LALQAKQYGDFDRYVLALSWQTGFCQSQHDRNRNERDECRLQTETTNKAD
FLTVHGLWPGLPKSVAARGVDERRWMRFGCATRPIPNLPEARASRMCSSP
ETGLSLETAAKLSEVMPGAGGRSCLERYEYAKHGACFGFDPDAYFGTMVR
LNQEIKESEAGKFLADNYGKTVSRRDFDAAFAKSWGKENVKAVKLTCQGN
PAYLTEIQISIKADAINAPLSANSFLPQPHPGNCGKTFVIDKAGY

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 2z70 Chain A Residue 246

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2z70 Nonspecific base recognition mediated by water bridges and hydrophobic stacking in ribonuclease I from Escherichia coli
• Resolution: 1.7 Å
• Binding residue (original residue number in PDB): Q26 D241 K242 G244
• Binding residue (residue number reindexed from 1): Q26 D241 K242 G244
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 4.6.1.21: Enterobacter ribonuclease.

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0004519 endonuclease activity
• GO:0008847 Enterobacter ribonuclease activity
• GO:0016829 lyase activity
• GO:0033897 ribonuclease T2 activity

Biological Process

• GO:0006401 RNA catabolic process

Cellular Component

• GO:0005737 cytoplasm
• GO:0030288 outer membrane-bounded periplasmic space
• GO:0042597 periplasmic space

External links

• PDB: RCSB:2z70, PDBe:2z70, PDBj:2z70
• PDBsum: 2z70
• PubMed: 18305191
• UniProt: P21338|RNI_ECOLI Ribonuclease I (Gene Name=rna)