Structure of PDB 2z1y Chain A Binding Site BS02

Receptor Information
>2z1y Chain A (length=389) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LSWSEAFGKGAGRIQASTIRELLKGILSFAGGLPAPELFPKEEAAEAAAR
ILREKGEVALQYSPTEGYAPLRAFVAEWIGVRPEEVLITTGSQQALDLVG
KVFLDEGSPVLLEAPSYMGAIQAFRLQGPRFLTVPAGEEGPDLDALEEVL
KRERPRFLYLIPSFQNPTGGLTPLPARKRLLQMVMERGLVVVEDDAYREL
YFGEARLPSLFELAREAGYPGVIYLGSFSKVLSPGLRVAFAVAHPEALQK
LVQAKQGADLHTPMLNQMLVHELLKEGFSERLERVRRVYREKAQAMLHAL
DREVPKEVRYTRPKGGMFVWMELPKGLSAEGLFRRALEENVAFVPGGPFF
ANGGGENTLRLSYATLDREGIAEGVRRLGRALKGLLALV
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain2z1y Chain A Residue 1400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB2z1y alpha-Aminoadipate aminotransferase from an extremely thermophilic bacterium, Thermus thermophilus
Resolution1.75 Å
Binding residue
(original residue number in PDB)		G99 S100 Q101 Y125 N174 D202 Y205 S235 S237 K238 R245
Binding residue
(residue number reindexed from 1)		G91 S92 Q93 Y117 N166 D194 Y197 S227 S229 K230 R237
Annotation score1
Enzymatic activity
Enzyme Commision number 2.6.1.39: 2-aminoadipate transaminase.
Gene Ontology
Molecular Function
GO:0008483 transaminase activity
GO:0030170 pyridoxal phosphate binding
GO:0047536 2-aminoadipate transaminase activity
Biological Process
GO:0009058 biosynthetic process
GO:0019878 lysine biosynthetic process via aminoadipic acid
GO:1901605 alpha-amino acid metabolic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:2z1y, PDBe:2z1y, PDBj:2z1y
PDBsum2z1y
PubMed
UniProtQ72LL6|LYSN_THET2 2-aminoadipate transaminase (Gene Name=lysN)

[Back to BioLiP]