Structure of PDB 2y1h Chain A Binding Site BS02

Receptor Information
>2y1h Chain A (length=262) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGVGLVDCHCHLSAPDFDRDLDDVLEKAKKANVVALVAVAEHSGEFEKIM
QLSERYNGFVLPCLGVHPVQRSVTLKDLDVALPIIENYKDRLLAIGEVGL
DFSPRFAGTGEQKEEQRQVLIRQIQLAKRLNLPVNVHSRSAGRPTINLLQ
EQGAEKVLLHAFDGRPSVAMEGVRAGYFFSIPPSIIRSGQKQKLVKQLPL
TSICLETDSPALGPEKQVRNEPWNISISAEYIAQVKGISVEEVIEVTTQN
ALKLFPKLRHLL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain2y1h Chain A Residue 1274 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2y1h Crystal Structure of the Human Tatd-Domain Protein 3 (Tatdn3)
Resolution2.5 Å
Binding residue
(original residue number in PDB)		H12 H14 E107 D218
Binding residue
(residue number reindexed from 1)		H9 H11 E97 D208
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.21.-
Gene Ontology
Molecular Function
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0046872 metal ion binding
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion

View graph for
Molecular Function
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Cellular Component
External links
PDB RCSB:2y1h, PDBe:2y1h, PDBj:2y1h
PDBsum2y1h
PubMed
UniProtQ17R31|TATD3_HUMAN Putative deoxyribonuclease TATDN3 (Gene Name=TATDN3)

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