Structure of PDB 2xs3 Chain A Binding Site BS02

Receptor Information

>2xs3 Chain A (length=166) Species: 28112 (Tannerella forsythia) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YVLQGSKWNKTTLKYYIYNSSSHLTTTERENAIRSAFALWSDKSTLSFIQ
VYNPNQADIKIKWEKGNHGDGYPFDGNTGILAHAFYPPPAGGNYAGHLHF
DDDENWSINGSGIDLITVAAHEIGHLLGIEHSNVSSALMYPYYTGIKRQL
DNDDCLAVWDLYGYPF

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

2xs3 Chain A Residue 998 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2xs3 The Structure of the Catalytic Domain of Tannerella Forsythia Karilysin Reveals It is a Bacterial Xenologue of Animal Matrix Metalloproteinases.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	H102 D104 H117 H133
Binding residue (residue number reindexed from 1)	H68 D70 H83 H99
Annotation score	4

Enzymatic activity

Catalytic site (original residue number in PDB)	H155 E156 H159 H165
Catalytic site (residue number reindexed from 1)	H121 E122 H125 H131
Enzyme Commision number	3.4.24.-

Gene Ontology

	Molecular Function
GO:0004222	metalloendopeptidase activity
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding

	Biological Process
GO:0006508	proteolysis

	Cellular Component
GO:0031012	extracellular matrix

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Cellular Component

External links

PDB	RCSB:2xs3, PDBe:2xs3, PDBj:2xs3
PDBsum	2xs3
PubMed	21166898
UniProt	D0EM77\|KLY_TANFA Karilysin (Gene Name=kly)

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