Structure of PDB 2xay Chain A Binding Site BS02

Receptor Information
>2xay Chain A (length=728) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NLLVTKRDGSTERINLDKIHRVLDWAAEGLHNVSISQVELRSHIQFYDGI
KTSDIHETIIKAAADLISRDAPDYQYLAARLAIFHLRKKAYGQFEPPALY
DHVVKMVEMGKYDNHLLEDYTEEEFKQMDTFIDHDRDMTFSYAAVKQLEG
KYLVQNRVTGEIYESAQFLYILVAACLFSNYPRETRLQYVKRFYDAVSTF
KISLPTPIMSGVRTPTRQFSSCVLIECGDSLDSINATSSAIVKYVSQRAG
IGINAGRIRALGSPFHTGCIPFYKHFQTAVKSCSQGGVRGGAATLFYPMW
HLEVESLLVLKNNRGVEGNRVRHMDYGVQINKLMYTRLLKGEDITLFSPS
DVPGLYDAFFADQEEFERLYTKYEKDDSIRKQRVKAVELFSLMMQERAST
GRIYIQNVDHCNTHSPFDPAIAPVRQSNLALEIALPTKPLNDVNDENGEI
ALCTLSAFNLGAINNLDELEELAILAVRALDALLDYQDYPIPAAKRGAMG
RRTLGIGVINFAYYLAKHGKRYSDGSANNLTHKTFEAIQYYLLKASNELA
KEQGACPWFNETTYAKGILPIDTYKKDLDTIANEPLHYDWEALRESIKTH
GLRNSTLSALMPSETSSQISNATNGIEPPRGYVSIKASKDGILRQVVPDY
EHLHDAYELLWEMPGNDGYLQLVGIMQKFIDQSISANTNYDPSRFPSGKV
PMQQLLKDLLTAYKFGVKTLYYQNTRDG
Ligand information
Receptor-Ligand Complex Structure
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PDB2xay Site-Specific Incorporation of 3-Nitrotyrosine as a Probe of Pk(A) Perturbation of Redox-Active Tyrosines in Ribonucleotide Reductase.
Resolution2.65 Å
Binding residue
(original residue number in PDB)		A559 K560 Q562 G563 A564 H609
Binding residue
(residue number reindexed from 1)		A550 K551 Q553 G554 A555 H600
Enzymatic activity
Catalytic site (original residue number in PDB) C225 N437 A439 E441 C462 Y730 Y731
Catalytic site (residue number reindexed from 1) C222 N428 A430 E432 C453 Y721 Y722
Enzyme Commision number 1.17.4.1: ribonucleoside-diphosphate reductase.
Gene Ontology
Molecular Function
GO:0004748 ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016491 oxidoreductase activity
GO:0042802 identical protein binding
GO:0044183 protein folding chaperone
Biological Process
GO:0006457 protein folding
GO:0009185 ribonucleoside diphosphate metabolic process
GO:0009263 deoxyribonucleotide biosynthetic process
GO:0009265 2'-deoxyribonucleotide biosynthetic process
GO:0015949 nucleobase-containing small molecule interconversion
Cellular Component
GO:0005829 cytosol
GO:0005971 ribonucleoside-diphosphate reductase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2xay, PDBe:2xay, PDBj:2xay
PDBsum2xay
PubMed20518462
UniProtP00452|RIR1_ECOLI Ribonucleoside-diphosphate reductase 1 subunit alpha (Gene Name=nrdA)

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