Structure of PDB 2x2e Chain A Binding Site BS02

Receptor Information
>2x2e Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MEDLIPLVNRLQDAFSAIGQNADLDLPQIAVVGGQSAGKSSVLENFVGRD
FLPRGSGIVTRRPLVLQLVNATTEYAEFLHCKGKKFTDFEEVRLEIEAET
DRVTGTNKGISPVPINLRVYSPHVLNLTLVDLPGMTKVPVGDQPPDIEFQ
IRDMLMQFVTKENCLILAVSPANSDLANSDALKVAKEVDPQGQRTIGVIT
KLDLMDEGTDARDVLENKLLPLRRGYIGVVNRSQKDIDGKKDITAALAAE
RKFFLSHPSYRHLADRMGTPYLQKVLNQQLTNHIRDTLPGLRNKLQSQLL
SIEKEVEEYKNFRPDKHGTDSRVDEMLRMYHALKEALSIIG
Ligand information
Ligand IDALF
InChIInChI=1S/Al.4FH/h;4*1H/q+3;;;;/p-4
InChIKeyUYOMQIYKOOHAMK-UHFFFAOYSA-J
SMILES
SoftwareSMILES
ACDLabs 10.04
CACTVS 3.341
OpenEye OEToolkits 1.5.0		F[Al-](F)(F)F
FormulaAl F4
NameTETRAFLUOROALUMINATE ION
ChEMBL
DrugBankDB04444
ZINC
PDB chain2x2e Chain A Residue 1745 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2x2e G Domain Dimerization Controls Dynamin'S Assembly-Stimulated Gtpase Activity.
Resolution2.0 Å
Binding residue
(original residue number in PDB)		S41 K44 V64 T65 G139
Binding residue
(residue number reindexed from 1)		S36 K39 V59 T60 G134
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.5: dynamin GTPase.
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:2x2e, PDBe:2x2e, PDBj:2x2e
PDBsum2x2e
PubMed20428113
UniProtQ05193|DYN1_HUMAN Dynamin-1 (Gene Name=DNM1)

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