Structure of PDB 2wcp Chain A Binding Site BS02

Receptor Information
>2wcp Chain A (length=208) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MQVNRLPFFTNHFFDTYLLISEDTPVGSSVTQLLARDMDNDPLVFGVSGE
EASRFFAVEPDTGVVWLRQPLDRETKSEFTVEFSVSDHQGVITRKVNIQV
GDVNDNAPTFHNQPYSVRIPENTPVGTPIFIVNATDPDLGAGGSVLYSFQ
PPSPFFAIDSARGIVTVIQELDYEVTQAYQLTVNATDQDKTRPLSTLANL
AIIITDLE
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2wcp Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2wcp Structural Determinants of Cadherin-23 Function in Hearing and Deafness.
Resolution1.98 Å
Binding residue
(original residue number in PDB)		E22 E74 D102 V103 D105 D138
Binding residue
(residue number reindexed from 1)		E22 E74 D102 V103 D105 D138
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
GO:0098609 cell-cell adhesion
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2wcp, PDBe:2wcp, PDBj:2wcp
PDBsum2wcp
PubMed20399731
UniProtQ99PF4|CAD23_MOUSE Cadherin-23 (Gene Name=Cdh23)

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