Structure of PDB 2v3z Chain A Binding Site BS02
Receptor Information
>2v3z Chain A (length=440) Species:
562
(Escherichia coli) [
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SEISRQEFQRRRQALVEQMQPGSAALIFAAPEVTRSADSEYPYRQNSDFW
YFTGFNEPEAVLVLIKSDDTHNHSVLFNRVRDLTAEIWFGRRLGQDAAPE
KLGVDRALAFSEINQQLYQLLNGLDVVYHAQGEYAYADVIVNSALEKLRK
GSRQNLTAPATMIDWRPVVHEMRLFKSPEEIAVLRRAGEITAMAHTRAME
KCRPGMFEYHLEGEIHHEFNRHGARYPSYNTIVGSGENGCILHYTENECE
MRDGDLVLIDAGCEYKGYAGDITRTFPVNGKFTQAQREIYDIVLESLETS
LRLYRPGTSILEVTGEVVRIMVSGLVKLGILKGDVDELIAQNAHRPFFMH
GLSHWLGLDVHDVGVYGQDRSRILEPGMVLTVAPGLYIAPDAEVPEQYRG
IGIRIEDDIVITETGNENLTASVVKKPEEIEALMVAARKQ
Ligand information
Ligand ID
MN
InChI
InChI=1S/Mn/q+2
InChIKey
WAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
Software
SMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0
[Mn+2]
CACTVS 3.341
[Mn++]
Formula
Mn
Name
MANGANESE (II) ION
ChEMBL
DrugBank
DB06757
ZINC
PDB chain
2v3z Chain A Residue 1441 [
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Receptor-Ligand Complex Structure
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PDB
2v3z
Complexes of Mutants of Escherichia Coli Aminopeptidase P and the Tripeptide Substrate Valproleu.
Resolution
1.56 Å
Binding residue
(original residue number in PDB)
D271 H354 E406
Binding residue
(residue number reindexed from 1)
D271 H354 E406
Annotation score
4
Enzymatic activity
Catalytic site (original residue number in PDB)
D38 H243 D260 D271 H350 H354 H361 A383 Y387 R404 E406
Catalytic site (residue number reindexed from 1)
D38 H243 D260 D271 H350 H354 H361 A383 Y387 R404 E406
Enzyme Commision number
3.4.11.9
: Xaa-Pro aminopeptidase.
Gene Ontology
Molecular Function
GO:0004177
aminopeptidase activity
GO:0005515
protein binding
GO:0008235
metalloexopeptidase activity
GO:0008237
metallopeptidase activity
GO:0030145
manganese ion binding
GO:0042802
identical protein binding
GO:0046872
metal ion binding
GO:0046914
transition metal ion binding
GO:0070006
metalloaminopeptidase activity
Biological Process
GO:0006508
proteolysis
GO:0051289
protein homotetramerization
Cellular Component
GO:0005737
cytoplasm
GO:0005829
cytosol
GO:0032991
protein-containing complex
View graph for
Molecular Function
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Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:2v3z
,
PDBe:2v3z
,
PDBj:2v3z
PDBsum
2v3z
PubMed
17983589
UniProt
P15034
|AMPP_ECOLI Xaa-Pro aminopeptidase (Gene Name=pepP)
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