Structure of PDB 2uvv Chain A Binding Site BS02

Receptor Information

>2uvv Chain A (length=342) Species: 273057 (Saccharolobus solfataricus P2)

MIVLFVDFDYFYAQVEEVLNPSLKGKPVVVCVFSGRFEDSGAVATANYEA
RKFGVKAGIPIVEAKKILPNAVYLPMRKEVYQQVSSRIMNLLREYSEKIE
IASIDEAYLDISDKVRDYREAYNLGLEIKNKILEKEKITVTVGISKNKVF
AKIAADMAKPNGIKVIDDEEVKRLIRELDIADVPGIGNITAEKLKKLGIN
KLVDTLSIEFDKLKGMIGEAKAKYLISLARDEYNEPIRTRVRKSIGRIVT
MKRNSRNLEEIKPYLFRAIEESYYKLDKRIPKAIHVVAVTEDLDIVSRGR
TFPHGISKETAYSESVKLLQKILEEDERKIREIGVRFSKFIE

Ligand information

>2uvv Chain T (length=16)

acggaatccttccccc

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2uvv Hydrogen Bonding of 7,8-Dihydro-8-Oxodeoxyguanosine with a Charged Residue in the Little Finger Domain Determines Miscoding Events in Sulfolobus Solfataricus DNA Polymerase Dpo4.
• Resolution: 2.2 Å
• Binding residue (original residue number in PDB): S34 G41 A42 G218 A220 R242 K243 S244 I245 G246 R247 I248 T250 K275 R331 R336
• Binding residue (residue number reindexed from 1): S34 G41 A42 G218 A220 R242 K243 S244 I245 G246 R247 I248 T250 K275 R331 R336

Enzymatic activity

• Enzyme Commision number: 2.7.7.7: DNA-directed DNA polymerase.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003677 DNA binding
• GO:0003684 damaged DNA binding
• GO:0003887 DNA-directed DNA polymerase activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006260 DNA replication
• GO:0006261 DNA-templated DNA replication
• GO:0006281 DNA repair
• GO:0006974 DNA damage response
• GO:0042276 error-prone translesion synthesis

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2uvv, PDBe:2uvv, PDBj:2uvv
• PDBsum: 2uvv
• PubMed: 17468100
• UniProt: Q97W02|DPO4_SACS2 DNA polymerase IV (Gene Name=dbh)