Structure of PDB 2uuv Chain A Binding Site BS02

Receptor Information
>2uuv Chain A (length=523) Species: 44689 (Dictyostelium discoideum) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HIDLYQQIKWNGWGDTRKFLHQLKPSGTIAMTTPEVSSVPLPSLRGFIKK
ELTFVLDETPALQIENIHVDPPKQYPEFVRELKAFFLPDQLKDDKLARIT
HTFGKSLRDLIRVRIGQVKNAPDLIVLPHSHEEVERLVQLAHKYNVVIIP
MGGGSNIVGAIEPVSNERFTVSIDMRRMNKVLWVDRREMTACIQVGIMGP
ELEKQLHKQGVSLGHDPDSFEFSTLGGWLATCSSGHQSDKYGDIEDMAVS
FRTVTPTGTLELRGINYKHIILGSEGTLGIITEAVMKVHAVPQAVEYYGF
LFPTFAHAVSALQQIRSSEVIPTMIRVYDPEETQLSFAWKPTSAMVKKYL
HYIRSFDFKNVCLSIIGFEGPKKVVDFHRTSVFDILSKNAAFGLGSAPGK
TWAEKRYDLPYIRDFLLDHNMWVDVAETTVSYANLQTLWKDAKQTFVKHF
KDQGIPAWICAHISHTYTNGVCLYFIFASKQNYIEAKKLMTDIIFKYGGS
RGWINVYRSLKETIDPKDICNPR
Ligand information
Ligand IDPL3
InChIInChI=1S/C16H34O/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17/h17H,2-16H2,1H3
InChIKeyBXWNKGSJHAJOGX-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04OCCCCCCCCCCCCCCCC
CACTVS 3.341
OpenEye OEToolkits 1.5.0		CCCCCCCCCCCCCCCCO
FormulaC16 H34 O
NameHEXADECAN-1-OL
ChEMBLCHEMBL706
DrugBankDB09494
ZINCZINC000008214519
PDB chain2uuv Chain A Residue 1586 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2uuv The Crucial Step in Ether Phospholipid Biosynthesis: Structural Basis of a Noncanonical Reaction Associated with a Peroxisomal Disorder.
Resolution1.99 Å
Binding residue
(original residue number in PDB)		S125 L126 R447 D458 V459 W492
Binding residue
(residue number reindexed from 1)		S106 L107 R413 D424 V425 W458
Annotation score1
Enzymatic activity
Enzyme Commision number 2.5.1.26: alkylglycerone-phosphate synthase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008609 alkylglycerone-phosphate synthase activity
GO:0016740 transferase activity
GO:0042802 identical protein binding
GO:0043178 alcohol binding
GO:0050660 flavin adenine dinucleotide binding
GO:0071949 FAD binding
Biological Process
GO:0006629 lipid metabolic process
GO:0008610 lipid biosynthetic process
GO:0008611 ether lipid biosynthetic process
Cellular Component
GO:0005777 peroxisome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2uuv, PDBe:2uuv, PDBj:2uuv
PDBsum2uuv
PubMed17562315
UniProtO96759|ADAS_DICDI Alkyldihydroxyacetonephosphate synthase (Gene Name=eapA)

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