Structure of PDB 2r7g Chain A Binding Site BS02

Receptor Information
>2r7g Chain A (length=336) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NTIQQLMMILNSASDQPSENLISYFNNCTVNPKESILKRVKDIGYIFKEK
FAKAVGQGCVEIGSQRYKLGVRLYYRVMESMLKSEEERLSIQNFSKLLND
NIFHMSLLACALEVVMATYSRSTGTDLSFPWILNVLNLKAFDFYKVIESF
IKAEGNLTREMIKHLERCEHRIMESLAWLSDSPLFDLIKQSKDKSTSLSL
FYKKVYRLAYLRLNTLCERLLSEHPELEHIIWTLFQHTLQNEYELMRDRH
LDQIMMCSMYGICKVKNIDLKFKIIVTAYKDLPHAVQETFKRVLIKEEEY
DSIIVFYNSVFMQRLKTNILQYASTRPPTLSPIPHI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2r7g Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor
Resolution1.671 Å
Binding residue
(original residue number in PDB)		Y709 K713 K720 F721 I753 Y756 N757 M761
Binding residue
(residue number reindexed from 1)		Y260 K264 K271 F272 I304 Y307 N308 M312
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0006357 regulation of transcription by RNA polymerase II
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:2r7g, PDBe:2r7g, PDBj:2r7g
PDBsum2r7g
PubMed17974914
UniProtP06400|RB_HUMAN Retinoblastoma-associated protein (Gene Name=RB1)

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