Structure of PDB 2r72 Chain A Binding Site BS02

Receptor Information
>2r72 Chain A (length=765) Species: 10995 (Infectious bursal disease virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DVEELLIPKVWVPPEDPLASPSRLAKFLRENGYKVLQPRSLPENEEYETD
QILPDLAWMRQILKPTLSLPIGDQEYFPKYYPTHRPSKEKPNAYPPDIAL
LKQMIYLFLQVPEANEGLKDEVTLLTQNIRDKAYGSGTYMGQANRLVAMK
EVATGRNPNKDPLKLGYTFESIAQLLDITLPVGPPGDDKPWVPLTRVPSR
MLVLTGDVDVEDYLPKINLKSSSGLPYVGRTKGETIGEMIAISNQFLREL
STLLKQGAGTKGSNKKKLLSMLSDYWYLSCGLLFPKAERYDKSTWLTKTR
NIWSAPSPTHLMISMITWPVMSNSPNNVLNIEGCPSLYKFNPFRGGLNRI
VEWILAPEEPKALVYADNIYIVHSNTWYSIDLEKGEANCTRQHMQAAMYY
ILTRGWSDNGDPMFNQTWATFAMNIAPALVVDSSCLIMNLQIKTYGQGSG
NAATFINNHLLSTLVLDQWNLMRQPRPDSEEFKSIEDKLGINFKIERSID
DIRGKLRQLVLLAQPGYLSGGVEPEQSSPTVELDLLGWSATYSKDLGIYV
PVLDKERLFCSAAYPKGVENKSLKSKVGIEQAYKVVRYEALRLVGGWNYP
LLNKACKNNAGAARRHLEAKGFPLDEFLAEWSELSEFGEAFEGFNIKLTV
TSESLAELNKPVPPKPPNVNRPVNTGGLKAVSNALKTGRYRNEAGLSGLV
LLATARSRLQDAVKAKAEAEKLHKSKPDADWFERSETLSDLLEKADIASK
VAHSALVETSDALEA
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain2r72 Chain A Residue 848 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2r72 Activation mechanism of a noncanonical RNA-dependent RNA polymerase.
Resolution3.15 Å
Binding residue
(original residue number in PDB)		N403 Y405 I415
Binding residue
(residue number reindexed from 1)		N368 Y370 I380
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.48: RNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003968 RNA-dependent RNA polymerase activity
GO:0005525 GTP binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0001172 RNA-templated transcription
GO:0018144 RNA-protein covalent cross-linking
GO:0019079 viral genome replication
Cellular Component
GO:0044423 virion component

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2r72, PDBe:2r72, PDBj:2r72
PDBsum2r72
PubMed18077388
UniProtQ9Q6Q5|RDRP_IBDV RNA-directed RNA polymerase (Gene Name=VP1)

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