Structure of PDB 2qkb Chain A Binding Site BS02

Receptor Information
>2qkb Chain A (length=152) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMGDFVVVYTDGCCSSNGRRRPRAGIGVYWGPGHPLNVGIRLPGRQTN
QRAEIHAACKAIEQAKTQNINKLVLYTNSMFTINGITNWVQGWKKNGWKT
SAGKEVINKEDFVALERLTQGMDIQWMHVPGHSGFIGNEEADRLAREGAK
QS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2qkb Structure of Human RNase H1 Complexed with an RNA/DNA Hybrid: Insight into HIV Reverse Transcription
Resolution2.4 Å
Binding residue
(original residue number in PDB)		N151 G152 R179 T181 N182 Q183 W221 W225 T232 S233 V238 I239 N240
Binding residue
(residue number reindexed from 1)		N19 G20 R47 T49 N50 Q51 W89 W93 T100 S101 V106 I107 N108
Enzymatic activity
Enzyme Commision number 3.1.26.4: ribonuclease H.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0004523 RNA-DNA hybrid ribonuclease activity

View graph for
Molecular Function
External links
PDB RCSB:2qkb, PDBe:2qkb, PDBj:2qkb
PDBsum2qkb
PubMed17964265
UniProtO60930|RNH1_HUMAN Ribonuclease H1 (Gene Name=RNASEH1)

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