Structure of PDB 2qb7 Chain A Binding Site BS02

Receptor Information
>2qb7 Chain A (length=393) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RKTVPEFLAHLKSLPISKIASNDVLTICVGNESADMDSIASAITYSYCQY
IYNEGTYSEEKKKGSFIVPIIDIPREDLSLRRDVMYVLEKLKIKEEELFF
IEDLKSLKQNVSQGTELNSYLVDNNDTPKNLKNYIDNVVGIIDHHFDLQK
HLDAEPRIVKVSGSCSSLVFNYWYEKLQGDREVVMNIAPLLMGAILIDTS
NMRRKVEESDKLAIERCQAVLSGAVNEVSAQGLEDSSEFYKEIKSRKNDI
KGFSVSDILKKDYKQFNFQGKGHKGLEIGLSSIVKRMSWLFNEHGGEADF
VNQCRRFQAERGLDVLVLLTSWRKAGDSHRELVILGDSNVVRELIERVSD
KLQLQLFGGNLDGGVAMFKQLNVEATRKQVVPYLEEAYSNLEE
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain2qb7 Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2qb7 The crystal structure of the cytosolic exopolyphosphatase from Saccharomyces cerevisiae reveals the basis for substrate specificity.
Resolution1.6 Å
Binding residue
(original residue number in PDB)		D39 D127 H149
Binding residue
(residue number reindexed from 1)		D35 D123 H145
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.1.11: exopolyphosphatase.
Gene Ontology
Molecular Function
GO:0004309 exopolyphosphatase activity
GO:0005524 ATP binding
GO:0016462 pyrophosphatase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006798 polyphosphate catabolic process
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2qb7, PDBe:2qb7, PDBj:2qb7
PDBsum2qb7
PubMed17599355
UniProtP38698|PPX1_YEAST Polyphosphatase (Gene Name=PPX1)

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