Structure of PDB 2q4r Chain A Binding Site BS02

Receptor Information
>2q4r Chain A (length=240) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PGPALCLFDVDGTLTAPRQKITKEMDDFLQKLRQKIKIGVVGGSDFEKVQ
EQLGNDVVEKYDYVFPENGLVAYKDGKLLCRQNIQSHLGEALIQDLINYC
LSYIAKIKLPKKRGTFIEFRNGMLNVSPIGRSCSQEERIEFYELDKKENI
RQKFVADLRKEFAGKGLTFSIGGQISFDVFPDGWDKRYCLRHVENDGYKT
IYFFGDKTMNDHEIFTDPRTMGYSVTAPEDTRRICELLFS
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain2q4r Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2q4r Ensemble refinement of protein crystal structures: validation and application.
Resolution2.09 Å
Binding residue
(original residue number in PDB)		F221 T222 D223 T226 G228
Binding residue
(residue number reindexed from 1)		F215 T216 D217 T220 G222
Annotation score1
Enzymatic activity
Enzyme Commision number 5.4.2.8: phosphomannomutase.
Gene Ontology
Molecular Function
GO:0004615 phosphomannomutase activity
GO:0005515 protein binding
GO:0016853 isomerase activity
GO:0046872 metal ion binding
Biological Process
GO:0006013 mannose metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0009298 GDP-mannose biosynthetic process
GO:0019309 mannose catabolic process
GO:0061728 GDP-mannose biosynthetic process from mannose
GO:0061729 GDP-mannose biosynthetic process from fructose-6-phosphate
GO:0141199 GDP-mannose biosynthetic process from glucose
Cellular Component
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0043025 neuronal cell body

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2q4r, PDBe:2q4r, PDBj:2q4r
PDBsum2q4r
PubMed17850744
UniProtO15305|PMM2_HUMAN Phosphomannomutase 2 (Gene Name=PMM2)

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