Structure of PDB 2pvf Chain A Binding Site BS02

Receptor Information

>2pvf Chain A (length=288) Species: 9606 (Homo sapiens)

ELPEDPKWEFPRDKLTLGKPLGEGAFGQVVMAEAVGIDKDKPVTVAVKML
KDDATEKDLSDLVSEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEYASK
GNLREYLRARRPPGMEYSYQMTFKDLVSCTYQLARGMEYLASQKCIHRDL
AARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWMAPEALFD
RVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPAN
CTNELYMMMRDCWHAVPSQRPTFKQLVEDLDRILTLTT

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2pvf Chain A Residue 301

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2pvf A molecular brake in the kinase hinge region regulates the activity of receptor tyrosine kinases.
• Resolution: 1.8 Å
• Binding residue (original residue number in PDB): N631 D644
• Binding residue (residue number reindexed from 1): N154 D167
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D626 A628 R630 N631 D644
• Catalytic site (residue number reindexed from 1): D149 A151 R153 N154 D167
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:2pvf, PDBe:2pvf, PDBj:2pvf
• PDBsum: 2pvf
• PubMed: 17803937
• UniProt: P21802|FGFR2_HUMAN Fibroblast growth factor receptor 2 (Gene Name=FGFR2)