Structure of PDB 2pnq Chain A Binding Site BS02

Receptor Information

>2pnq Chain A (length=382) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

LTPPQVNSILKANEYSFKVPEFDGKNVSSILGFDSNRLPANAPIEDRRSA
TTCLQTRGMLLGVFDGHAGCACSQAVSERLFYYIAVSLLPHETLLEIENA
VELLPILQWHKHPNDYFSKEASKLYFNGLRTYWQELIDLDIDVKEALINA
FKRLDNDISLEAQVGDPNSFLNYLVLRVAFSGATACVAHVDGVDLHVANT
GDSRAMLGVQEEDGSWSAVTLSNDHNAQNERELQRLKLEHPKNEAKSVVK
QDRLLGLLMPFRAFGDVKFKWSIDLQKRVIESGPDPPNYHTPPYLTAEPE
VTYHRLRPQDKFLVLATDGLWETMHRQDVVRIVGEYLTGMHHQQQNAATH
LIRHAVGYRDDITIIVVQFNSHVVGAYQNQEQ

Ligand information

Ligand ID

InChI

InChI=1S/Mg/q+2

InChIKey

JLVVSXFLKOJNIY-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mg+2]
CACTVS 3.341	[Mg++]

Formula

Name

MAGNESIUM ION

PDB chain

2pnq Chain A Residue 502 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	2pnq Crystal structure of pyruvate dehydrogenase phosphatase 1 and its functional implications.
Resolution	1.81 Å
Binding residue (original residue number in PDB)	D73 D347 D445
Binding residue (residue number reindexed from 1)	D65 D318 D360
Annotation score	1

Enzymatic activity

Enzyme Commision number

3.1.3.43: [pyruvate dehydrogenase (acetyl-transferring)]-phosphatase.

Gene Ontology

	Molecular Function
GO:0004722	protein serine/threonine phosphatase activity
GO:0043169	cation binding

	Biological Process
GO:0006470	protein dephosphorylation

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Molecular Function

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Biological Process

External links

PDB	RCSB:2pnq, PDBe:2pnq, PDBj:2pnq
PDBsum	2pnq
PubMed	17532339
UniProt	O88483\|PDP1_RAT [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (Gene Name=Pdp1)

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