Structure of PDB 2pi5 Chain A Binding Site BS02

Receptor Information
>2pi5 Chain A (length=862) Species: 10760 (Escherichia phage T7) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
IAKNDFSDIELAAIPFNTLADHYGERLAREQLALEHESYEMGEARFRKMF
PLITTLLPKMIARINDWFEEVKAKRGKRPTAFQFLQEIKPEAVAYITIKT
TLACLTSADNTTVQAVASAIGRAIEDEARFGRIRDLEAKHFKKNVEEQLN
KRVGHVYKKAFMQVVEADMLSKGLLGGEAWSSWHKEDSIHVGVRCIEMLI
ESTGMVSLHRQNAGVVGQDSETIELAPEYAEAIATRAGALAGISPMFQPC
VVPPKPWTGITGGGYWANGRRPLALVRTHSKKALMRYEDVYMPEVYKAIN
IAQNTAWKINKKVLAVANVITKWKHCPVEDIPAIEREELPMKPEDIDMNP
EALTAWKRAAAAVYRKDKARKSRRISLEFMLEQANKFANHKAIWFPYNMD
WRGRVYAVSMFNPQGNDMTKGLLTLAKGKPIGKEGYYWLKIHGANCAGVD
KVPFPERIKFIEENHENIMACAKSPLENTWWAEQDSPFCFLAFCFEYAGV
QHHGLSYNCSLPLAFDGSCSGIQHFSAMLRDEVGGRAVNLLPSETVQDIY
GIVAKKVNEILQADAINGTDNEVVTVTDENTGEISEKVKLGTKALAGQWL
AYGVTRSVTKRSVMTLAYGSKEFGFRQQVLEDTIQPAIDSGKGLMFTQPN
QAAGYMAKLIWESVSVTVVAAVEAMNWLKSAAKLLAAEVKDKKTGEILRK
RCAVHWVTPDGFPVWQEYKKPIQTRLNLMFLGQFRLQPTINTNKDSEIDA
HKQESGIAPNFVHSQDGSHLRKTVVWAHEKYGIESFALIHDSFGTIPADA
ANLFKAVRETMVDTYESCDVLADFYDQFADQLHESQLDKMPALPAKGNLN
LRDILESDFAFA
Ligand information
Receptor-Ligand Complex Structure
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PDB2pi5 Mechanism for de novo RNA synthesis and initiating nucleotide specificity by t7 RNA polymerase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		R96 K98 P100 H211 R215 L747 N748
Binding residue
(residue number reindexed from 1)		R75 K77 P79 H190 R194 L726 N727
Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
GO:0019083 viral transcription
GO:0039695 DNA-templated viral transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2pi5, PDBe:2pi5, PDBj:2pi5
PDBsum2pi5
PubMed17512007
UniProtP00573|RPOL_BPT7 T7 RNA polymerase (Gene Name=1)

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