Structure of PDB 2ozp Chain A Binding Site BS02

Receptor Information

>2ozp Chain A (length=342) Species: 300852 (Thermus thermophilus HB8)

KKTLSIVGASGYAGGEFLRLALSHPYLEVKQVTSRRFAGEPVHFVHPNLR
GRTNLKFVPPEKLEPADILVLALPHGVFAREFDRYSALAPVLVDLSADFR
LKDPELYRRYYGEHPRPDLLGRFVYAVPELYREALKGADWIAGAGCNATA
TLLGLYPLLKAGVLKPTPIFVTLLISTSAGGAEASPASHHPERAGSIRVY
KPTGHRHTAEVVENLPGRPEVHLTAIATDRVRGILMTAQCFVQDGWSERD
VWQAYREAYAGEPFIRLVKQKKGVHRYPDPRFVQGTNYADIGFELEEDTG
RLVVMTAIDNLVKGTAGHALQALNVRMGWPETLGLDFPGLHP

Ligand information

• Ligand ID: AZI
• InChI: InChI=1S/N3/c1-3-2/q-1
• InChIKey: IVRMZWNICZWHMI-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  CACTVS 3.341
  OpenEye OEToolkits 1.5.0: [N-]=[N+]=[N-]
• Formula: N3
• Name: AZIDE ION
• ChEMBL: CHEMBL79455
• PDB chain: 2ozp Chain A Residue 1008

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2ozp Crystal structure of N-acetyl-gamma-glutamyl-phosphate reductase (TTHA1904) from Thermus thermophilus
• Resolution: 2.01 Å
• Binding residue (original residue number in PDB): H46 R53
• Binding residue (residue number reindexed from 1): H43 R50
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.2.1.103: [amino-group carrier protein]-6-phospho-L-2-aminoadipate reductase.

Gene Ontology

Molecular Function

• GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity
• GO:0016491 oxidoreductase activity
• GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
• GO:0043870 N-acetyl-gamma-aminoadipyl-phosphate reductase activity
• GO:0051287 NAD binding
• GO:0070401 NADP+ binding

Biological Process

• GO:0006526 L-arginine biosynthetic process
• GO:0009085 lysine biosynthetic process
• GO:0019878 lysine biosynthetic process via aminoadipic acid

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:2ozp, PDBe:2ozp, PDBj:2ozp
• PDBsum: 2ozp
• UniProt: Q5SH26