Structure of PDB 2oxz Chain A Binding Site BS02

Receptor Information
>2oxz Chain A (length=158) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPVWRKHYITYRINNYTPDMNREDVDYAIRKAFQVWSNVTPLKFSKINTG
MADILVVFARGAHGDDHAFDGKGGILAHAFGPGSGIGGDAHFDEDEFWTT
HSGGTNLFLTAVHEIGHSLGLGHSSDPKAVMFPTYKYVDINTFRLSADDI
RGIQSLYG
Ligand information
Receptor-Ligand Complex Structure
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PDB2oxz Snapshots of the reaction mechanism of matrix metalloproteinases.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		G179 L181 H218 E219 P238 T239 Y240
Binding residue
(residue number reindexed from 1)		G74 L76 H113 E114 P133 T134 Y135
Enzymatic activity
Catalytic site (original residue number in PDB) H218 E219 H222 H228
Catalytic site (residue number reindexed from 1) H113 E114 H117 H123
Enzyme Commision number 3.4.24.65: macrophage elastase.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0031012 extracellular matrix

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2oxz, PDBe:2oxz, PDBj:2oxz
PDBsum2oxz
PubMed17096442
UniProtP39900|MMP12_HUMAN Macrophage metalloelastase (Gene Name=MMP12)

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