Structure of PDB 2nmv Chain A Binding Site BS02

Receptor Information
>2nmv Chain A (length=620) Species: 1423 (Bacillus subtilis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DRFELVKYQPQGDQPKAIEKLVKGIQEGKKHQTLLGATGTGKTFTVSNLI
KEVNKPTLVIAHNKTLAGQLYSEFKEFFPNNAVEYFVSYYDYYQPEAYVP
QTDTFIEKDASINDEIDKLRHSATSALFERRDVIIIASVSCIYGLGSPEE
YREMVVSLRTEMEIERNELLRKLVDIQYARNDIDFQRGTFRVRGDVVEIF
PASRDEHCVRVEFFGDEIERIREVDALTGEILGDRDHVAIFPASHFVTRA
EKMEKAIQNIEKELEEQLKVMHENGKLLEAQRLEQRTRYDLEMMREMGFC
SGIENYSRHLTLRPPGSTPYTLLDYFPDDFMIVVDESHVTIPQVRGMFNG
DQARKQVLVDHGFRLPSALDNRPLRFEEFEKHMHNIVYVSATPGPYEIEH
TDEMVEQIIRPTGLLDPLIDVRPIEGQIDDLIGEIQARIERNERVLVTTL
TKKMSEDLTDYLKEIGIKVNYLHSEIKTLERIEIIRDLRLGKYDVLVGIN
LLREGLDIPEVSLVAILDADKEGFLRSERSLIQTIGRAARNAEGRVIMYA
DKITKSMEIAINETKRRREQQERFNEEHGITPKTINKKERQKVVEQMEHE
MKEAAKALDFERAAELRDLL
Ligand information
Ligand IDFLU
InChIInChI=1S/C20H12O5/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24/h1-10,21H,(H,23,24)
InChIKeyYKGGGCXBWXHKIZ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04O=C(O)c4ccccc4C=1c3c(OC=2C=1C=CC(=O)C=2)cc(O)cc3
CACTVS 3.341OC(=O)c1ccccc1C2=C3C=CC(=O)C=C3Oc4cc(O)ccc24
OpenEye OEToolkits 1.5.0c1ccc(c(c1)C2=C3C=CC(=O)C=C3Oc4c2ccc(c4)O)C(=O)O
FormulaC20 H12 O5
Name2-(6-HYDROXY-3-OXO-3H-XANTHEN-9-YL)-BENZOIC ACID;
FLUORESCEIN
ChEMBLCHEMBL177756
DrugBank
ZINCZINC000003872582
PDB chain2nmv Chain D Residue 600 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2nmv Damage detection by the UvrABC pathway: crystal structure of UvrB bound to fluorescein-adducted DNA
Resolution2.95 Å
Binding residue
(original residue number in PDB)		Y74 S75 N116 I119
Binding residue
(residue number reindexed from 1)		Y71 S72 N113 I116
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0005524 ATP binding
GO:0009381 excinuclease ABC activity
GO:0016787 hydrolase activity
GO:0016887 ATP hydrolysis activity
Biological Process
GO:0006281 DNA repair
GO:0006289 nucleotide-excision repair
GO:0009432 SOS response
Cellular Component
GO:0005737 cytoplasm
GO:0009380 excinuclease repair complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2nmv, PDBe:2nmv, PDBj:2nmv
PDBsum2nmv
PubMed17097086
UniProtP37954|UVRB_BACSU UvrABC system protein B (Gene Name=uvrB)

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