Structure of PDB 2nce Chain A Binding Site BS02

Receptor Information
>2nce Chain A (length=139) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HTEKRGRIYLKAEVTDEKLHVTVRDAKNLIPMDPNGLSDPYVKLKLIPDP
KNESKQKTKTIRSTLNPQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRND
FMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEG
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain2nce Chain A Residue 302 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB2nce Ca2+-sensing domain contributes to auto-inhibition of protein kinase Calpha through interactions with C-terminal tail
ResolutionN/A
Binding residue
(original residue number in PDB)		M186 D187 D246 D248 D254
Binding residue
(residue number reindexed from 1)		M32 D33 D92 D94 D100
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.11.13: protein kinase C.
External links
PDB RCSB:2nce, PDBe:2nce, PDBj:2nce
PDBsum2nce
PubMed
UniProtP05696|KPCA_RAT Protein kinase C alpha type (Gene Name=Prkca)

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