Structure of PDB 2ju4 Chain A Binding Site BS02

Receptor Information
>2ju4 Chain A (length=87) Species: 9913 (Bos taurus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MNLEPPKAECRSATRVMGGPCTPRKGPPKCKQRQTRQCKSKPPKKGVQGC
GDDIPGMEGCGTDITVICPWEACNHCELHELAQYGIC
Ligand information
Ligand IDRCY
InChIInChI=1S/C12H20N2O3/c1-11(2)7-8(12(3,4)14(11)17)13-9(15)5-6-10(13)16/h8,17H,5-7H2,1-4H3/t8-/m1/s1
InChIKeyBGLGHMPQDJUKJG-MRVPVSSYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.7.6CC1(CC(C(N1[O])(C)C)N2C(=O)CCC2=O)C
CACTVS 3.370CC1(C)C[C@@H](N2C(=O)CCC2=O)C(C)(C)N1[O]
ACDLabs 12.01ON2C(CC(N1C(=O)CCC1=O)C2(C)C)(C)C
CACTVS 3.370CC1(C)C[CH](N2C(=O)CCC2=O)C(C)(C)N1[O]
OpenEye OEToolkits 1.7.6CC1(C[C@H](C(N1[O])(C)C)N2C(=O)CCC2=O)C
FormulaC12 H19 N2 O3
Name(3'R)-1'-oxyl-2',2',5',5'-tetramethyl-1,3'-bipyrrolidine-2,5-dione;
3-Maleimido-PROXYL (bound form)
ChEMBL
DrugBank
ZINC
PDB chain2ju4 Chain A Residue 121 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2ju4 Intrinsically disordered gamma-subunit of cGMP phosphodiesterase encodes functionally relevant transient secondary and tertiary structure.
ResolutionN/A
Binding residue
(original residue number in PDB)		V16 M17 C21
Binding residue
(residue number reindexed from 1)		V16 M17 C21
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.4.35: 3',5'-cyclic-GMP phosphodiesterase.
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004117 calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity
GO:0008270 zinc ion binding
GO:0016787 hydrolase activity
GO:0030553 cGMP binding
GO:0047555 3',5'-cyclic-GMP phosphodiesterase activity
GO:0048101 calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity
GO:0060090 molecular adaptor activity
Biological Process
GO:0007601 visual perception
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045745 positive regulation of G protein-coupled receptor signaling pathway
Cellular Component
GO:0042622 photoreceptor outer segment membrane
GO:0097381 photoreceptor disc membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2ju4, PDBe:2ju4, PDBj:2ju4
PDBsum2ju4
PubMed18230733
UniProtP04972|CNRG_BOVIN Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit gamma (Gene Name=PDE6G)

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