Structure of PDB 2jd5 Chain A Binding Site BS02

Receptor Information

>2jd5 Chain A (length=353) Species: 4932 (Saccharomyces cerevisiae)

FHPAFKGEPYKDARYILVRKLGWGHFSTVWLAKDMVNNTHVAMKIVRGDK
VYTEAAEDEIKLLQRVNDADNTKEDSMGANHILKLLDHFNHKGPNGVHVV
MVFEVLGENLLALIKKYEHRGIPLIYVKQISKQLLLGLDYMHRRCGIIHT
DIKPENVLMEIVDSPENLIQIKIADLGNACWYDEHYTNSIQTREYRSPEV
LLGAPWGCGADIWSTACLIFELITGDFLFTKDDDHIAQIIELLGELPSYL
LRNGKYTRTFFNSLLRNISKLKFWPLEDVLTEKYKFSKDEAKEISDFLSP
MLQLDPRKRADAGGLVNHPWLKDTLGMEEIRVPDRELYGSGSDIPGWFEE
VRD

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 2jd5 Chain A Residue 1739

Receptor-Ligand Complex Structure

Structure summary

• PDB: 2jd5 The Rgg Domain of Npl3P Recruits Sky1P Through Docking Interactions
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): N299 D550
• Binding residue (residue number reindexed from 1): N156 D175
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D294 K296 N299 D550 T567
• Catalytic site (residue number reindexed from 1): D151 K153 N156 D175 T192
• Enzyme Commision number: 2.7.11.1: non-specific serine/threonine protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:2jd5, PDBe:2jd5, PDBj:2jd5
• PDBsum: 2jd5
• PubMed: 17239901
• UniProt: Q03656|SKY1_YEAST Serine/threonine-protein kinase SKY1 (Gene Name=SKY1)