Structure of PDB 2j5t Chain A Binding Site BS02

Receptor Information
>2j5t Chain A (length=355) Species: 562 (Escherichia coli) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DSQTLVVKLGTSVLTGGSRRLNRAHIVELVRQCAQLHAAGHRIVIVTSGA
IAAGREHLGYPELPATIASKQLLAAVGQSRLIQLWEQLFSIYGIHVGQML
LTRADMEDRERFLNARDTLRALLDNNVVPVINENDAVATAEIKVGDNDNL
SALAAILAGADKLLLLTDQKGLYTADPRSNPQAELIKDVYGIDDALRAIG
GMSTKLQAADVACRAGIDTIIAAGSKPGVIGDVMEGISVGTLFHAQATPL
ENRKRWIFGAPPAGEITVDEGATAAILERGSSLLPKGIKSVTGNFSRGEV
IRICNLEGRDIAHGVSRYNSDALRRIAGHHSQEIDAILGYEYGPVAVHRD
DMITR
Ligand information
Ligand IDGLU
InChIInChI=1S/C5H9NO4/c6-3(5(9)10)1-2-4(7)8/h3H,1-2,6H2,(H,7,8)(H,9,10)/t3-/m0/s1
InChIKeyWHUUTDBJXJRKMK-VKHMYHEASA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=C(O)C(N)CCC(=O)O
OpenEye OEToolkits 1.7.0C(CC(=O)O)C(C(=O)O)N
OpenEye OEToolkits 1.7.0C(CC(=O)O)[C@@H](C(=O)O)N
CACTVS 3.370N[C@@H](CCC(O)=O)C(O)=O
CACTVS 3.370N[CH](CCC(O)=O)C(O)=O
FormulaC5 H9 N O4
NameGLUTAMIC ACID
ChEMBLCHEMBL575060
DrugBankDB00142
ZINCZINC000001482113
PDB chain2j5t Chain A Residue 1374 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2j5t A Novel Two-Domain Architecture within the Amino Acid Kinase Enzyme Family Revealed by the Crystal Structure of Escherichia Coli Glutamate 5-Kinase.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		S50 G51 A52 D137 D148 N149
Binding residue
(residue number reindexed from 1)		S48 G49 A50 D135 D146 N147
Annotation score5
Enzymatic activity
Enzyme Commision number 2.7.2.11: glutamate 5-kinase.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003723 RNA binding
GO:0004349 glutamate 5-kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:1901973 proline binding
Biological Process
GO:0006561 proline biosynthetic process
GO:0008652 amino acid biosynthetic process
GO:0016310 phosphorylation
GO:0055129 L-proline biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:2j5t, PDBe:2j5t, PDBj:2j5t
PDBsum2j5t
PubMed17321544
UniProtP0A7B5|PROB_ECOLI Glutamate 5-kinase (Gene Name=proB)

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