Structure of PDB 2isq Chain A Binding Site BS02

Receptor Information
>2isq Chain A (length=320) Species: 3702 (Arabidopsis thaliana) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRIAKDVTELIGNTPLVYLNNVAEGCVGRVAAKLEMMEPCSSVKDRIGFS
MISDAEKKGLIKPGESVLIEPTSGNTGVGLAFTAAAKGYKLIITMPASMS
TERRIILLAFGVELVLTDPAKGMKGAIAKAEEILAKTPNGYMLQQFENPA
NPKIHYETTGPEIWKGTGGKIDGFVSGIGTGGTITGAGKYLKEQNANVKL
YGVEPVESAILSGGKPGPHKIQGIGAGFIPSVLNVDLIDEVVQVSSDESI
DMARQLALKEGLLVGISSGAAAAAAIKLAQRPENAGKLFVAIFPSFGERY
LSTVLFDATRKEAEAMTFEA
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain2isq Chain A Residue 400 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB2isq Structural basis for interaction of o-acetylserine sulfhydrylase and serine acetyltransferase in the Arabidopsis cysteine synthase complex.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		K46 N77 G179 G181 T182 G183 T185 G225 S269 P296
Binding residue
(residue number reindexed from 1)		K44 N75 G177 G179 T180 G181 T183 G223 S267 P294
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K46 S269
Catalytic site (residue number reindexed from 1) K44 S267
Enzyme Commision number 2.5.1.47: cysteine synthase.
Gene Ontology
Molecular Function
GO:0003729 mRNA binding
GO:0004124 cysteine synthase activity
GO:0005515 protein binding
GO:0016740 transferase activity
Biological Process
GO:0006535 cysteine biosynthetic process from serine
GO:0009567 double fertilization forming a zygote and endosperm
GO:0009860 pollen tube growth
GO:0019344 cysteine biosynthetic process
GO:0046686 response to cadmium ion
Cellular Component
GO:0000325 plant-type vacuole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005777 peroxisome
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0009507 chloroplast
GO:0009570 chloroplast stroma
GO:0048046 apoplast

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:2isq, PDBe:2isq, PDBj:2isq
PDBsum2isq
PubMed17194764
UniProtP47998|CYSK1_ARATH Cysteine synthase 1 (Gene Name=OASA1)

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